Issue 43, 2021

Molecular platforms based on biocompatible photoreactions for photomodulation of biological targets

Abstract

Photoirradiation provides a convenient and biocompatible approach for spatiotemporal modulation of biological systems with photoresponsive components. The construction of molecular platforms with a photoresponse to be integrated into biomolecules for photomodulation has been of great research interest in optochemical biology. In this review, we summarize typical molecular platforms that are integratable with biomolecules for photomodulation purposes. We categorize these molecular platforms according to their excitation light source, namely ultraviolet (UV), visible (Vis) or near-infrared (NIR) light. The protype chemistry of these molecular platforms is introduced along with an overview of their most recent applications for spatiotemporal regulation of biomolecular function in living cells or mice models. Challenges and the outlook are also presented. We hope this review paper will contribute to further progress in the development of molecular platforms and their biomedical use.

Graphical abstract: Molecular platforms based on biocompatible photoreactions for photomodulation of biological targets

Article information

Article type
Review Article
Submitted
17 Aug. 2021
Accepted
16 Sept. 2021
First published
17 Sept. 2021

Org. Biomol. Chem., 2021,19, 9358-9368

Molecular platforms based on biocompatible photoreactions for photomodulation of biological targets

C. Zhu, T. Kou, A. A. Kadi, J. Li and Y. Zhang, Org. Biomol. Chem., 2021, 19, 9358 DOI: 10.1039/D1OB01613J

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