Issue 20, 2021

Dual modulation sites for a reversible fluorescent probe for GSH over Cys/Hcy

Abstract

An abnormal concentration of glutathione (GSH) is a health-associated risk factor and it is an important signal for diseases such as Parkinson's disease, liver injury and cancer. Therefore, understanding the real-time level of GSH is essential for the diagnosis, treatment, and pathological research of related diseases. At present, a few reversible GSH fluorescent probes have been developed, but they mostly exhibit similar chemical reactivities towards Cys and GSH. In this work, based on sulfhydryl and carboxyl groups in GSH, a dual-reversible-site probe was constructed with HBT (2-(2′-hydroxyphenyl)benzothiazole) and coumarin linked by α,β-unsaturated ketone units, achieving higher selectivity for GSH over Cys and Hcy. This probe was successfully employed to image the intracellular GSH levels, good for an in-depth understanding of GSH-related events.

Graphical abstract: Dual modulation sites for a reversible fluorescent probe for GSH over Cys/Hcy

Supplementary files

Article information

Article type
Paper
Submitted
26 Marts 2021
Accepted
20 Apr. 2021
First published
21 Apr. 2021

New J. Chem., 2021,45, 9096-9101

Dual modulation sites for a reversible fluorescent probe for GSH over Cys/Hcy

H. Ren, F. Huo and C. Yin, New J. Chem., 2021, 45, 9096 DOI: 10.1039/D1NJ01490K

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