Issue 96, 2021

Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications

Abstract

Enzymatic noncovalent synthesis enables the spatiotemporal control of multimolecular crowding in cells, thus offering a unique opportunity for modulating cellular functions. This article introduces some representative enzymes and molecular building blocks for generating peptide assemblies as multimolecular crowding in cells, highlights the relevant biomedical applications, such as anticancer therapy, molecular imaging, trafficking proteins, genetic engineering, artificial intracellular filaments, cell morphogenesis, and antibacterial, and briefly discusses the promises of ENS as a multistep molecular process in biology and medicine.

Graphical abstract: Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications

Supplementary files

Article information

Article type
Feature Article
Submitted
01 Okt. 2021
Accepted
11 Nov. 2021
First published
11 Nov. 2021

Chem. Commun., 2021,57, 12870-12879

Author version available

Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications

M. Yi, W. Tan, J. Guo and B. Xu, Chem. Commun., 2021, 57, 12870 DOI: 10.1039/D1CC05565H

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