Issue 88, 2021

Co(iii)-catalysed regioselective linear C(8)–H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

Abstract

A regioselective C8 linear olefination of isoquinoline-1H-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(III) catalysis. This is an exclusive report on the C8 functionalization of isoquinolone using non-noble transition metal complexes. Experimental and computational mechanistic studies have also been performed to depict the reaction pathway.

Graphical abstract: Co(iii)-catalysed regioselective linear C(8)–H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

Supplementary files

Article information

Article type
Communication
Submitted
17 Aug. 2021
Accepted
29 Sept. 2021
First published
30 Sept. 2021

Chem. Commun., 2021,57, 11613-11616

Co(III)-catalysed regioselective linear C(8)–H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

D. Chandra, N. Kumar, Sumit, D. Parmar, P. Gupta and U. Sharma, Chem. Commun., 2021, 57, 11613 DOI: 10.1039/D1CC04541E

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