Issue 55, 2021

Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

Abstract

Asymmetric allylic CH alkylation of 1,4-pentadienes with α-angelica lactones has been developed by tri-axial phosphoramidite-palladium catalysis. This reaction can tolerate a range of functional groups under mild conditions, furnishing versatile chiral γ,γ-disubstituted butenolides in high yields with good to high levels of stereoselectivity.

Graphical abstract: Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

Supplementary files

Article information

Article type
Communication
Submitted
29 Apr. 2021
Accepted
10 Jūn. 2021
First published
11 Jūn. 2021

Chem. Commun., 2021,57, 6748-6751

Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

Z. Dai, P. Wang and L. Gong, Chem. Commun., 2021, 57, 6748 DOI: 10.1039/D1CC02295D

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