Issue 46, 2020

Recent advances in the synthesis of plakortin-type polyketides

Abstract

Plakortin-type polyketides represent a growing family of sponge-derived marine natural products that display notable structural and biological diversity. In particular, a series of polycyclic plakortin polyketides, namely hippolachnin A and gracilioethers, have been identified in recent years, which attract immense interest from the synthetic community owing to their unique molecular architectures and promising biomedical potential. A number of elegant total syntheses of these targets and some synthetic studies have been performed through either bio-inspired or rationally designed strategies. This focused review aims to provide an up-to-date summary of the progress in the chemical synthesis of plakortin polyketides, with an emphasis on the key synthetic elements enabling the rapid assembly of their core skeletons.

Graphical abstract: Recent advances in the synthesis of plakortin-type polyketides

Article information

Article type
Review Article
Submitted
19 Sept. 2020
Accepted
27 Okt. 2020
First published
27 Okt. 2020

Org. Biomol. Chem., 2020,18, 9371-9384

Recent advances in the synthesis of plakortin-type polyketides

Q. Li, H. Yang and Y. Tang, Org. Biomol. Chem., 2020, 18, 9371 DOI: 10.1039/D0OB01930E

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