Issue 13, 2020

Multifunctionality and cytotoxicity of a layered coordination polymer

Abstract

This work reports the synthesis and multifunctionality of 2D layered coordination polymers formulated as [Ln2(H3nmp)2xH2O (1, where Ln = Sm3+, Eu3+, Tb3+, Dy3+, Ho3+, Er3+ and Y3+) (x = 1 to 4). We describe detailed synthesis of the materials using various methods [typical hydrothermal reaction (HT), microwave-assisted synthesis (MWAS) and one-pot method (OP)], while discussing the various crystal morphologies which can be fine tuned by varying systematically the conditions. We further explore the multifunctionality of this material by studying its heterogeneous catalytic activity in the ring opening of styrene oxide, its photoluminescence behaviour and its cytotoxicity. A conversion of 88%/100% yield at 4 h/24 h reaction respectively, with excellent selectivity towards 2-methoxy-2-phenylethanol product (100%) was observed. Photoluminescence properties of the optically-active [Eu2(H3nmp)2xH2O (1Eu) and the mixed-lanthanide [(Gd0.95Eu0.5)2(H3nmp)2xH2O (1GdEu), on the other hand, show potential use for UV-to-visible light converters, with lifetimes of 2.31 ± 0.01 and 2.61 ± 0.01 ms at ambient temperature for 1Eu and 1GdEu samples. Preliminary cytotoxic studies showed no effects on metabolic activity of both in vitro human epithelial kidney (HK-2) and human hepatocellular carcinoma (HepG2) cell lines. A reduction of NR uptake was, however, observed indicating some cytotoxic effect on lysosomal activity.

Graphical abstract: Multifunctionality and cytotoxicity of a layered coordination polymer

Supplementary files

Article information

Article type
Paper
Submitted
30 Okt. 2019
Accepted
11 Dec. 2019
First published
17 Janv. 2020

Dalton Trans., 2020,49, 3989-3998

Multifunctionality and cytotoxicity of a layered coordination polymer

P. Silva, R. F. Mendes, C. Fernandes, A. C. Gomes, D. Ananias, F. Remião, F. Borges, A. A. Valente and F. A. Almeida Paz, Dalton Trans., 2020, 49, 3989 DOI: 10.1039/C9DT04211C

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