Issue 20, 2020

Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs

Abstract

The uncapped tripeptide DPhe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling DPhe-Phe-Leu-Asp-Val contains the LDV bioadhesive motif for β1 integrin activation. Hydrogels made of the two peptides successfully mimic fibronectin of the extracellular matrix and lead to high cell viability, adhesion, and spreading.

Graphical abstract: Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec. 2019
Accepted
31 Janv. 2020
First published
31 Janv. 2020

Chem. Commun., 2020,56, 3015-3018

Bioadhesive supramolecular hydrogel from unprotected, short D,L-peptides with Phe-Phe and Leu-Asp-Val motifs

M. C. Cringoli, C. Romano, E. Parisi, L. J. Waddington, M. Melchionna, S. Semeraro, R. De Zorzi, M. Grönholm and S. Marchesan, Chem. Commun., 2020, 56, 3015 DOI: 10.1039/C9CC09947F

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