Issue 4, 2020

Photoinduced deaminative strategies: Katritzky salts as alkyl radical precursors

Abstract

Primary amines are one of the most predominant functional groups found in organic molecules. These entities help form the chemical architecture of natural products, bioactive molecules, synthetic building blocks and catalysts. Due to their ubiquitous presence, the development of strategies for the construction of C–C or C–X bonds through deaminative processes is of high importance. Deaminative methods offer new possibilities on the retrosynthetic rationale, and enable late-stage-functionalization of complex structures. As a result of the recent development of photoinduced processes, a variety of photo-mediated deaminative protocols employing 2,4,6-triphenyl-pyridinium salts – Katritzky Salts – as activating agents have been recently realized. This review covers the most recent developments of deaminative strategies by using Katritzky Salts as alkyl radical reservoirs, with particular concern on photoinduced processes applied to organic synthesis.

Graphical abstract: Photoinduced deaminative strategies: Katritzky salts as alkyl radical precursors

Article information

Article type
Feature Article
Submitted
24 Okt. 2019
Accepted
03 Dec. 2019
First published
05 Dec. 2019

Chem. Commun., 2020,56, 503-514

Photoinduced deaminative strategies: Katritzky salts as alkyl radical precursors

J. T. M. Correia, V. A. Fernandes, B. T. Matsuo, J. A. C. Delgado, W. C. de Souza and M. W. Paixão, Chem. Commun., 2020, 56, 503 DOI: 10.1039/C9CC08348K

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