Issue 7, 2019

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Abstract

Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Article information

Article type
Review Article
Submitted
19 Sept. 2018
Accepted
18 Okt. 2018
First published
24 Okt. 2018

Org. Biomol. Chem., 2019,17, 1624-1633

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

F. L. Duecker, F. Reuß and P. Heretsch, Org. Biomol. Chem., 2019, 17, 1624 DOI: 10.1039/C8OB02325E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements