Issue 10, 2018

Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

Abstract

Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (e.g., hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(III) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(III) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution.

Graphical abstract: Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

Supplementary files

Article information

Article type
Paper
Submitted
08 Dec. 2017
Accepted
16 Marts 2018
First published
19 Marts 2018

New J. Chem., 2018,42, 8074-8087

Iron(III) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

X. Martin-Benlloch, A. Novodomska, D. Jacquemin, E. Davioud-Charvet and M. Elhabiri, New J. Chem., 2018, 42, 8074 DOI: 10.1039/C7NJ04867J

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