Issue 37, 2018

Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Abstract

Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

Graphical abstract: Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Supplementary files

Article information

Article type
Communication
Submitted
14 Maijs 2018
Accepted
17 Jūl. 2018
First published
17 Jūl. 2018

CrystEngComm, 2018,20, 5486-5489

Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

L. Liu, C. Wang, J. Dun, A. H. L. Chow and C. C. Sun, CrystEngComm, 2018, 20, 5486 DOI: 10.1039/C8CE00787J

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