Issue 9, 2018

A lanthanide functionalized MOF hybrid for ratiometric luminescence detection of an anthrax biomarker

Abstract

Dipicolinic acid (DPA) can serve as a convenient biomarker for Bacillus anthracis, which is an extremely hazardous pathogen and can be used as a biological weapon. Herein, we demonstrate a ratiometric luminescent sensor of DPA based on a dual-emissive MOF hybrid, which is developed by encapsulation of Tb3+ cations into an anionic MOF through a cation exchange process. The Tb3+@MOF hybrid well inherits the intrinsic ligand emission of the host framework and the Tb3+ emission. The parent framework can function as a host matrix to sensitize and protect the emission of incorporated Tb3+. The Tb3+ emission within the MOF hybrid is significantly enhanced in the presence of DPA molecules owing to the occurrence of antenna sensitization upon the formation of the Tb–DPA complex, while the ligand emission is insensitive to DPA. This unique ratiometric luminescence response of the Tb3+@MOF hybrid towards DPA can be exploited for sensitive self-calibrated detection of DPA. The Tb3+@MOF sensor shows a fast response rate, high sensitivity and selectivity with a limit of detection of 3.6 nM. Besides, the feasibility of this sensor operating in real samples is demonstrated by the good recovery of DPA in human serum. The present study provides a promising luminescent platform for routine analysis of an anthrax biomarker.

Graphical abstract: A lanthanide functionalized MOF hybrid for ratiometric luminescence detection of an anthrax biomarker

Supplementary files

Article information

Article type
Paper
Submitted
17 Nov. 2017
Accepted
20 Janv. 2018
First published
22 Janv. 2018

CrystEngComm, 2018,20, 1264-1270

A lanthanide functionalized MOF hybrid for ratiometric luminescence detection of an anthrax biomarker

D. Zhang, Y. Zhou, J. Cuan and N. Gan, CrystEngComm, 2018, 20, 1264 DOI: 10.1039/C7CE01994G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements