Issue 25, 2017

Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy

Abstract

Significant progress has been made in the use of injectable hydrogels as drug carrier systems to treat cancers by the peritumoral-localized co-delivery of multiple drugs with different therapeutic mechanisms. In this study, a novel, injectable self-crosslinking HA–SH hydrogel was able to concurrently encapsulate multiple drugs (sorafenib, doxorubicin, and metformin) to enhance chemotherapy efficacy. The hydrogel was relatively stable under physiological conditions and could quickly and directly release the loaded drugs to the tumor site in a reductive tumor microenvironment. The in vitro antitumor activity and cell-apoptosis assay demonstrated that the hydrogel loaded with multiple drugs (Gel + DS or Gel + DSM) showed obvious synergistic effects against breast cancer cells. The combinational chemotherapy enhanced the sensitivities of tumor cells and promoted tumor cell apoptosis after peritumoral administration. Compared with the single drug-loaded hydrogel, the hydrogel co-loaded with multiple drugs (Gel + DSM) showed the best tumor growth inhibition. Moreover, the monitoring of mice weight and ex vivo histological analysis of the main organs indicated that localized treatment with the hydrogel co-loaded with multiple drugs (Gel + DSM) obviously relieved the systemic toxicity and showed promise for inhibiting tumor metastasis, suggesting the superiority and potential application prospects of the injectable, self-crosslinking hydrogel co-loaded with multiple drugs.

Graphical abstract: Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy

Article information

Article type
Paper
Submitted
14 Apr. 2017
Accepted
20 Maijs 2017
First published
22 Maijs 2017

J. Mater. Chem. B, 2017,5, 4852-4862

Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy

M. He, J. Sui, Y. Chen, S. Bian, Y. Cui, C. Zhou, Y. Sun, J. Liang, Y. Fan and X. Zhang, J. Mater. Chem. B, 2017, 5, 4852 DOI: 10.1039/C7TB01026E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements