Issue 21, 2017

Molecular engineering solutions for therapeutic peptide delivery

Abstract

Proteins and their interactions in and out of cells must be well-orchestrated for the healthy functioning and regulation of the body. Even the slightest disharmony can cause diseases. Therapeutic peptides are short amino acid sequences (generally considered <50 amino acids) that can naturally mimic the binding interfaces between proteins and thus, influence protein–protein interactions. Because of their fidelity of binding, peptides are a promising next generation of personalized medicines to reinstate biological harmony. Peptides as a group are highly selective, relatively safe, and biocompatible. However, they are also vulnerable to many in vivo pharmacologic barriers limiting their clinical translation. Current advances in molecular, chemical, and nanoparticle engineering are helping to overcome these previously insurmountable obstacles and improve the future of peptides as active and highly selective therapeutics. In this review, we focus on self-assembled vehicles as nanoparticles to carry and protect therapeutic peptides through this journey, and deliver them to the desired tissue.

Graphical abstract: Molecular engineering solutions for therapeutic peptide delivery

Article information

Article type
Review Article
Submitted
21 Jūl. 2017
First published
13 Sept. 2017

Chem. Soc. Rev., 2017,46, 6553-6569

Molecular engineering solutions for therapeutic peptide delivery

H. Acar, J. M. Ting, S. Srivastava, J. L. LaBelle and M. V. Tirrell, Chem. Soc. Rev., 2017, 46, 6553 DOI: 10.1039/C7CS00536A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements