Issue 7, 2017

Ruthenium-catalyzed meta/ortho-selective C–H alkylation of azoarenes using alkyl bromides

Abstract

meta/ortho-Selective CAr–H (di)alkylation reactions of azoarenes have been achieved via [Ru(p-cymene)Cl2]2 catalyzed ortho-metalation using various types of alkyl bromides. Particularly, dual meta-alkylation of azoarene and reduction offer an attractive strategy for the synthesis of meta-alkylanilines, which are difficult to access via traditional aniline functionalization methods.

Graphical abstract: Ruthenium-catalyzed meta/ortho-selective C–H alkylation of azoarenes using alkyl bromides

Supplementary files

Article information

Article type
Communication
Submitted
22 Nov. 2016
Accepted
23 Dec. 2016
First published
23 Dec. 2016

Chem. Commun., 2017,53, 1261-1264

Ruthenium-catalyzed meta/ortho-selective C–H alkylation of azoarenes using alkyl bromides

G. Li, X. Ma, C. Jia, Q. Han, Y. Wang, J. Wang, L. Yu and S. Yang, Chem. Commun., 2017, 53, 1261 DOI: 10.1039/C6CC09323J

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