Issue 9, 2016

Biomolecular strategies to modulate the macrophage response to implanted materials

Abstract

The material-induced foreign body response is a major challenge for implanted medical devices. This review highlights recent developments in biomimetic approaches to create biomaterials that mitigate the host response to biomaterials. Specifically, we will describe strategies in which biomaterials are decorated with endogenously expressed biomolecules that naturally modulate the function of immune cells. These include molecules that directly bind to and interact with immune cells, as well as molecules that control complement activation or thrombosis and indirectly modulate immune cell function. We provide perspective on how these approaches may impact the design of materials for medical devices and tissue engineering.

Graphical abstract: Biomolecular strategies to modulate the macrophage response to implanted materials

Article information

Article type
Review Article
Submitted
07 Aug. 2015
Accepted
08 Sept. 2015
First published
09 Sept. 2015

J. Mater. Chem. B, 2016,4, 1600-1609

Biomolecular strategies to modulate the macrophage response to implanted materials

Y. K. Kim, E. Y. Chen and W. F. Liu, J. Mater. Chem. B, 2016, 4, 1600 DOI: 10.1039/C5TB01605C

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