Issue 12, 2016

Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

Abstract

Sheath-flow surface-enhanced Raman spectroscopy (SERS) was used for online detection and quantification of small molecules separated by liquid chromatography. A mixture of model metabolites (thiamine, folic acid, and riboflavin) was separated and characterized by UV-Vis and SERS detectors connected in series. Acetonitrile in the mobile phase provided an internal standard enabling quantitative detection across SERS experiments.

Graphical abstract: Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

Supplementary files

Article information

Article type
Communication
Submitted
22 Janv. 2016
Accepted
05 Apr. 2016
First published
05 Apr. 2016

Analyst, 2016,141, 3630-3635

Author version available

Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

A. Nguyen and Z. D. Schultz, Analyst, 2016, 141, 3630 DOI: 10.1039/C6AN00155F

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