Issue 5, 2015

Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Abstract

The definition of crystal morphologies in polymorphic systems is a fundamental area of crystal engineering with implications for down-stream processing and formulation, which make morphological studies highly relevant. There are few recent examples of such detailed studies in the literature and here we address the case of p-aminobenzoic acid (PABA), focusing on its two polymorphic forms, α and β. Using a combination of modelling techniques to create predicted morphologies, we interpret these in the light of experimental data recorded on crystals grown from a range of polar solvents. Preliminary discussion of the intermolecular interactions involved in crystal growth of both forms, allow us to explore the enhanced morphological importance of the (002) face in α PABA and of (10[1 with combining macron]) and (0[1 with combining macron]1) faces for β PABA. It is suggested that desolvation plays a paramount role.

Graphical abstract: Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Supplementary files

Article information

Article type
Paper
Submitted
11 Sept. 2014
Accepted
23 Okt. 2014
First published
30 Okt. 2014

CrystEngComm, 2015,17, 1015-1023

Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

R. A. Sullivan and R. J. Davey, CrystEngComm, 2015, 17, 1015 DOI: 10.1039/C4CE01857E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements