A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.
S. Chen, W. Wu, M. Hu, T. Ou, L. Gu, J. Tan and Z. Huang, Chem. Commun., 2014, 50, 12173 DOI: 10.1039/C4CC05394J
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