A copper-mediated direct insertion of alkenes into unstrained ring 2-aryl-1,3-indandiones provides a one-carbon ring expansion strategy for 1,4-naphthoquinone synthesis.
This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds.
Synthesis of functionalized 1,3-indandione containing spirocyclopentanes has been achieved in a highly diastereoselective manner in presence of catalytic amount of DABCO by the reaction of 2-(2′-ketoalkyl)-1,3-indandiones with nitrostyrenes.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
Intermolecular annulation reactions of 1-naphthyl-1,3-indandiones with alkenes proceed efficiently in the presence of a copper catalyst to generate spirocarbocycle compounds.