The “Circe effect” in supramolecular catalysis: the investment in entropy of CB[7] upon substrate binding accounts for the acceleration (kincluded/kbulk up to 104!) of the intramolecular Diels–Alder reaction of tertiary furfuryl amines.
The first total synthesis of type II (±)-abyssomicin 2, (±)-neoabyssomicin B via two pathways and a type I derivative are presented.
This study elucidates the role of the absolute configuration at the C-6 carbon of the substrate polyene in the stereocontrol of the IMDA reaction catalyzed by Fsa2 and Phm7, which construct different enantiomeric decalin skeletons.
This review describes enzyme-catalyzed reactions involving ambimodal transition states, and recent advances in understanding how enzymes control selectivity in such reactions.
Heterologous expression of biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new natural product variants.