Cubane-1,3-dicarboxamides as structural isosteres for isophthalamides in hydrogen bond templated interlocked molecules

Sean R. Barlow, Nathan R. Halcovitch, Geoffrey R. Akien, Susannah C. Coote and Nicholas H. Evans

Chem. Commun., 2024, 60, 11532
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Unveiling the energetic potential of azahomocubane (AHC): a new class of potential propellants, explosives and oxidizers

Sohan Lal, Haixiang Gao and Jean'ne M. Shreeve

Dalton Trans., 2025, 54, 4082
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(Bio)isosteres of ortho- and meta-substituted benzenes

H Erik Diepers and Johannes C L Walker

Beilstein J. Org. Chem., 2024, 20, 859
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Strategy for C−H Functionalization of Cubanes: From Stoichiometric Reaction to Catalytic Methodology

Masaki Hosaka, Shota Nagasawa and Yoshiharu Iwabuchi

Eur J Org Chem, 2024, 27
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Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity

Pablo Garrido-García, Irene Quirós, Paula Milán-Rois, Silvia Ortega-Gutiérrez, Mar Martín-Fontecha, Luis A. Campos, Álvaro Somoza, Israel Fernández, Thomas Rigotti and Mariola Tortosa

Nat. Chem., 2025, 17, 734
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Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds

Tomohiro Yasukawa, Katja S. Håheim and Janine Cossy

Helvetica Chimica Acta, 2024, 107
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Three-dimensional saturated C(sp3)-rich bioisosteres for benzene

Jet Tsien, Chao Hu, Rohan R. Merchant and Tian Qin

Nat Rev Chem, 2024, 8, 605
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A Simple [2 + 2] Photocycloaddition Reaction that Proceeds in an NMR Tube Illuminated by Daylight

Thomas Doig, Yuanyuan Du, Tomas Lebl, Meiyue Liu, Fraser Mealyou, Iain L. J. Patterson, Jasmine Rainer, Ryan Walker and Iain A. Smellie

J. Chem. Educ., 2025, 102, 2087
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Assessing the rigidity of cubanes and bicyclo(1.1.1)pentanes as benzene bioisosteres

Graham Pattison

Bioorganic & Medicinal Chemistry, 2024, 102, 117652
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Silver(I)-Catalyzed Synthesis of Cuneanes from Cubanes and their Investigation as Isosteres

Elliot Smith, Kieran D. Jones, Luke O’Brien, Stephen P. Argent, Christophe Salome, Quentin Lefebvre, Alain Valery, Mina Böcü, Graham N. Newton and Hon Wai Lam

J. Am. Chem. Soc., 2023, 145, 16365
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The Baeyer–Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols

Jasmine Hind, Ian. A. Fallis, James. A. Platts and Matthew Tredwell

Org. Lett., 2025, 27, 9218
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Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho-Substituted Benzenes

Oleh K. Smyrnov, Kostiantyn P. Melnykov, Olexandr Ye. Pashenko, Dmytro M. Volochnyuk and Serhiy V. Ryabukhin

Org. Lett., 2024, 26, 4808
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Catalytic Asymmetric Synthesis of Chiral Caged Hydrocarbons as Arenes Bioisosteres

Xue‐Chun Yang, Ji‐Jie Wang, Yuanjiu Xiao and Jian‐Jun Feng

Angew Chem Int Ed, 2025, 64
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Catalytic Asymmetric Synthesis of Chiral Caged Hydrocarbons as Arenes Bioisosteres

Xue‐Chun Yang, Ji‐Jie Wang, Yuanjiu Xiao and Jian‐Jun Feng

Angewandte Chemie, 2025, 137
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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp3)-Rich Benzene Bioisosteres

Xiaoshen Ma, Adam M. Beard, Samantha A. Burgess, Miroslawa Darlak, Justin A. Newman, Lisa M. Nogle, Mark J. Pietrafitta, David A. Smith, Xiao Wang and Lei Yue

J. Org. Chem., 2024, 89, 5010
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Catalytic asymmetric synthesis of meta benzene isosteres

Mingkai Zhang, Matthew Chapman, Bhagyesh R. Sarode, Bingcong Xiong, Hao Liang, James K. Chen, Eranthie Weerapana and James P. Morken

Nature, 2024, 633, 90
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Multigram Synthesis of 1,3-Disubstituted Cubane

Synfacts, 2024, 20, 0031
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