Nanomaterial journey in the gut: from intestinal mucosal interaction to systemic transport

Xin Qiao, Lin Bao, Guanyu Liu and Xuejing Cui

Nanoscale, 2024, 16, 19207
DOI: 10.1039/D4NR02480J

Hazard assessment of ingested polystyrene nanoplastics in Drosophila larvae

Mohamed Alaraby, Doaa Abass, Josefa Domenech, Alba Hernández and Ricard Marcos

Environ. Sci.: Nano, 2022, 9, 1845
DOI: 10.1039/D1EN01199E

Oral administration of silver nanomaterials affects the gut microbiota and metabolic profile altering the secretion of 5-HT in mice

Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao and Chunying Chen

J. Mater. Chem. B, 2023, 11, 1904
DOI: 10.1039/D2TB02756A

Release of microplastic fibres and fragmentation to billions of nanoplastics from period products: preliminary assessment of potential health implications

Leonardo Pantoja Munoz, Alejandra Gonzalez Baez, Diane Purchase, Huw Jones and Hemda Garelick

Environ. Sci.: Nano, 2022, 9, 606
DOI: 10.1039/D1EN00755F

Gut‐on‐a‐Chip Reveals Enhanced Peristalsis Reduces Nanoplastic‐Induced Inflammation

Junlei Han, Yushen Wang, Jiemeng Ding, Hao Chen, Chaoyang Shi, Xinyu Li, Zhipeng Xu, Jun Chen, Feng Kong and Li Wang

Small, 2025, 21
DOI: 10.1002/smll.202408208

Dysregulation of the microbiota-brain axis during long-term exposure to polystyrene nanoplastics in rats and the protective role of dihydrocaffeic acid

Wenbo Jiang, Cong Hu, Yunyan Chen, Yue Li, Xinyi Sun, Huanyu Wu, Ruiming Yang, Yiwei Tang, Fengru Niu, Wei Wei, Changhao Sun and Tianshu Han

Science of The Total Environment, 2023, 874, 162101
DOI: 10.1016/j.scitotenv.2023.162101

Mitigating microplastic-induced organ Damage: Mechanistic insights from the microplastic-macrophage axes

Yinxing Cui, Yuqi Wu, Pan Shi, Yan Ni, Huaying Zeng, Zhao Zhang, Chunling Zhao, Weichao Sun and Qian Yi

Redox Biology, 2025, 84, 103688
DOI: 10.1016/j.redox.2025.103688

Microplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats

Damir Suljević, Patrik Karlsson, Muhamed Fočak, Maja Mitrašinović Brulić, Jasmina Sulejmanović, Elma Šehović, Eva Särndahl, Magnus Engwall and Andi Alijagic

Environment International, 2025, 198, 109421
DOI: 10.1016/j.envint.2025.109421

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Madjid Djouina, Suzie Loison and Mathilde Body-Malapel

Microplastics, 2024, 3, 217
DOI: 10.3390/microplastics3020013

MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways

Ruixue Duo, Yining Wang, Quanzhi Ma, Xiaoyuan Wang, Yan Zhang and Haili Shen

Clin Rheumatol, 2025, 44, 2163
DOI: 10.1007/s10067-025-07406-y

Effect of Water Salinity, Dietary Potassium Carbonate, Vitamin D₃ Levels, and Vitamin D₃ Form (1α-Hydroxycholecalciferol) on Calcium and Phosphorus Digestibility and Tibia Bone Properties in Broilers

Hossein Esmaeili, Farzad Bagherzadeh-kasmani, Saeed Khalaji, Hossein N. Younesi and Mahmood Ghazaghi

J. Poult. Sci., 2025, 62, n/a
DOI: 10.2141/jpsa.2025020

Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

Xiaomei Wang, Kaili Deng, Pei Zhang, Qiqing Chen, Jason T. Magnuson, Wenhui Qiu and Yuping Zhou

Science of The Total Environment, 2024, 919, 170962
DOI: 10.1016/j.scitotenv.2024.170962

A novel tiRNA-Glu-CTC induces nanoplastics accelerated vascular smooth muscle cell phenotypic switching and vascular injury through mitochondrial damage

Min Zhang, Jun Shi, Huichao Pan, Jie Zhu, Xueting Wang, Lei Song and Huiping Deng

Science of The Total Environment, 2024, 912, 169515
DOI: 10.1016/j.scitotenv.2023.169515

Nanoplastic-Induced Biological Effects In Vivo and In Vitro: An Overview

Hongxin Xie, Xue Tian, Xiaoying Lin, Rui Chen, Saima Hameed, Liming Wang, Yong-Liang Yu, Bai Li and Yu-Feng Li

Reviews Env.Contamination (formerly:Residue Reviews), 2023, 261
DOI: 10.1007/s44169-023-00027-z

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

Yujiao He, Zhe Li, Tong Xu, Dongliu Luo, Qianru Chi, Yiming Zhang and Shu Li

Chemosphere, 2022, 307, 135662
DOI: 10.1016/j.chemosphere.2022.135662

Transport of microplastics in the body and interaction with biological barriers, and controlling of microplastics pollution

Lin Zhu, Caiyan Xie, Liangkai Chen, Xingyu Dai, Yuanzhong Zhou, Hong Pan and Kunming Tian

Ecotoxicology and Environmental Safety, 2023, 255, 114818
DOI: 10.1016/j.ecoenv.2023.114818

Simulated gastrointestinal digestion of polylactic acid (PLA) biodegradable microplastics and their interaction with the gut microbiota

C. Jiménez-Arroyo, A. Tamargo, N. Molinero, J.J. Reinosa, V. Alcolea-Rodriguez, R. Portela, M.A. Bañares, J.F. Fernández and M.V. Moreno-Arribas

Science of The Total Environment, 2023, 902, 166003
DOI: 10.1016/j.scitotenv.2023.166003

The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways

Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang and Ai Gao

Journal of Hazardous Materials, 2023, 458, 131949
DOI: 10.1016/j.jhazmat.2023.131949

Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Mario Romeo, Marcello Dallio, Fiammetta Di Nardo, Giuseppina Martinelli, Claudio Basile, Alessia Silvestrin, Giusy Senese, Annachiara Coppola, Carmine Napolitano, Angela Amoresano, Carlo Altucci and Alessandro Federico

Livers, 2025, 5, 21
DOI: 10.3390/livers5020021

Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice

Hong-Jia Huang, Yang Liu, Xiang Wang, Lu Huang, Da-Wei Li, Hong-Ye Li and Wei-Dong Yang

Ecotoxicology and Environmental Safety, 2024, 281, 116628
DOI: 10.1016/j.ecoenv.2024.116628

Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice

Hua Zha, Jiafeng Xia, Shengjie Li, Jiawen Lv, Aoxiang Zhuge, Ruiqi Tang, Shuting Wang, Kaiceng Wang, Kevin Chang and Lanjuan Li

Chemosphere, 2023, 310, 136764
DOI: 10.1016/j.chemosphere.2022.136764

Potential lifetime effects caused by cellular uptake of nanoplastics: A review

Yoojin Lee, Seongeun Cho, Kyungtae Park, Taihyun Kim, Jiyu Kim, Du-Yeol Ryu and Jinkee Hong

Environmental Pollution, 2023, 329, 121668
DOI: 10.1016/j.envpol.2023.121668

Nanoplastics exposure simplifies the network structure of sea cucumber (Apostichopus japonicus) gut microbiota and improves cluster randomness

Xinglong Xia, Luo Wang, Honglin Pei, Changkun Dong, Yanmin Zhang and Jun Ding

Environmental Pollution, 2024, 360, 124663
DOI: 10.1016/j.envpol.2024.124663

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

Federica Giambò, Chiara Costa, Michele Teodoro and Concettina Fenga

Front. Med., 2022, 9
DOI: 10.3389/fmed.2022.810397

The gut microbiota, a key to understanding the health implications of micro(nano)plastics and their biodegradation

Cristina Jiménez‐Arroyo, Alba Tamargo, Natalia Molinero and M. Victoria Moreno‐Arribas

Microbial Biotechnology, 2023, 16, 34
DOI: 10.1111/1751-7915.14182

Gut microbiota and hypertension: association, mechanisms and treatment

Zhihua Yang, Qingchun Wang, Yangxi Liu, Lin Wang, Zhao Ge, Zhenzhen Li, Shaoling Feng and Chongming Wu

Clinical and Experimental Hypertension, 2023, 45
DOI: 10.1080/10641963.2023.2195135

The wheel of time: The environmental dance of aged micro- and nanoplastics and their biological resonance

Hongjian Li, Lihua Bai, Sijia Liang, Xiru Chen, Xinyue Gu, Chao Wang and Cheng Gu

Eco-Environment & Health, 2025, 4, 100138
DOI: 10.1016/j.eehl.2025.100138

Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway

Wanzhen Wang, Jiafu Guan, Yueying Feng, Shanji Liu, Yu Zhao, Yuanyuan Xu, Hengyi Xu and Fen Fu

Toxics, 2023, 11, 225
DOI: 10.3390/toxics11030225

Sources, Degradation, Ingestion and Effects of Microplastics on Humans: A Review

Yan-Duan Lin, Ping-Hsiu Huang, Yu-Wei Chen, Chang-Wei Hsieh, You-Lin Tain, Bao-Hong Lee, Chih-Yao Hou and Ming-Kuei Shih

Toxics, 2023, 11, 747
DOI: 10.3390/toxics11090747

Morphological and lipid metabolism alterations in macrophages exposed to model environmental nanoplastics traced by high-resolution synchrotron techniques

Federica Zingaro, Alessandra Gianoncelli, Giacomo Ceccone, Giovanni Birarda, Domenico Cassano, Rita La Spina, Chiara Agostinis, Valentina Bonanni, Giuseppe Ricci and Lorella Pascolo

Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1247747

Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis

Weijia Liu, Bowen Zhang, Qianqian Yao, Xihua Feng, Tianling Shen, Peisen Guo, Panpan Wang, Yitong Bai, Bo Li, Peixi Wang, Ruiling Li, Zhi Qu and Nan Liu

Front. Public Health, 2023, 11
DOI: 10.3389/fpubh.2023.1103289

Environmental microplastics exposure decreases antioxidant ability, perturbs gut microbial homeostasis and metabolism in chicken

Aoyun Li, Yingli Wang, Muhammad Fakhar-e-Alam Kulyar, Mudassar Iqbal, Renhao Lai, Huaisen Zhu and Kun Li

Science of The Total Environment, 2023, 856, 159089
DOI: 10.1016/j.scitotenv.2022.159089

Maltol attenuates polystyrene nanoplastic-induced enterotoxicity by promoting AMPK/mTOR/TFEB-mediated autophagy and modulating gut microbiota

Ming-hui Jin, Jun-nan Hu, Ming Zhang, Zhaojie Meng, Guo-ping Shi, Zi Wang and Wei Li

Environmental Pollution, 2023, 322, 121202
DOI: 10.1016/j.envpol.2023.121202

Gut microbiota combined with metabolome dissects long-term nanoplastics exposure-induced disturbed spermatogenesis

Yan Zhou, Xiang Zhong, Liangkai Chen, Liming Gong, Lei Luo, Qian He, Lin Zhu and Kunming Tian

Ecotoxicology and Environmental Safety, 2023, 267, 115626
DOI: 10.1016/j.ecoenv.2023.115626

Size-dependent internalization of polystyrene microplastics as a key factor in macrophages and systemic toxicity

Wei-Qiang Luo, Meng-Ting Cao, Chen-Xuan Sun, Jun-Jian Wang, Meng-Xi Gao, Xue-Rui He, Le-Ning Dang, Yang-Yang Geng, Bing-Yao Li, Jing Li, Zhi-Cheng Shi and Xing-Rong Yan

Journal of Hazardous Materials, 2025, 490, 137701
DOI: 10.1016/j.jhazmat.2025.137701

The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review

Soroush Oraee, Mohammadreza Alinejadfard, Sajjad Mahdavi, Shahryar Rajai Firouzabadi, Sara Hatami, Ida Mohammadi, Yasaman Zarinfar and Isa Khaheshi

Toxicol. Environ. Health Sci., 2025, 17, 203
DOI: 10.1007/s13530-025-00248-w

An integrated analysis of the fecal metabolome and metagenome reveals the distinct effects of differentially charged nanoplastics on the gut microbiota-associated metabolites in mice

Miaomiao Teng, Xiaoli Zhao, Lingfeng Zhou, Hong Yan, Lihui Zhao, Jiaqi Sun, Yunxia Li, Wentao Zhu and Fengchang Wu

Science of The Total Environment, 2024, 906, 167287
DOI: 10.1016/j.scitotenv.2023.167287

Orally administered Bi2S3@SiO2 core-shell nanomaterials as gastrointestinal contrast agents and their influence on gut microbiota

Rui Chen, Ruyi Zhou, Jiyan Qiao, Yanan Yang, Xingfan Zhou, Ru Bai, Yuqian Wang, Liang Yan and Chongming Wu

Materials Today Bio, 2022, 13, 100178
DOI: 10.1016/j.mtbio.2021.100178

Polystyrene microplastics exacerbated liver injury from cyclophosphamide in mice: Insight into gut microbiota

Siyue Wen, Yu Zhao, Shanji Liu, Yanbiao Chen, Hongbin Yuan and Hengyi Xu

Science of The Total Environment, 2022, 840, 156668
DOI: 10.1016/j.scitotenv.2022.156668

Gut microbiota, a key to understanding the knowledge gaps on micro-nanoplastics-related biological effects and biodegradation

Jiping Wang, Yutong Wang, Zhenyu Li, Jie Wang, Hongbo Zhao and Xian Zhang

Science of The Total Environment, 2024, 944, 173799
DOI: 10.1016/j.scitotenv.2024.173799

Interactions between gut microbiota and emerging contaminants exposure: new and profound implications for human health

Feng Zhao, Zhaoyi Liu, Yuehua Wu, Jiao Wang, Yinyin Xia, Shuqun Cheng, Xuejun Jiang, Jun Zhang, Zhen Zou, Chengzhi Chen and Jingfu Qiu

Environ. Res. Commun., 2024, 6, 072001
DOI: 10.1088/2515-7620/ad5f7f

Transgenerational reproductive toxicity induced by carboxyl and amino charged microplastics at environmental concentrations in Caenorhabditis elegans: Involvement of histone methylation

Haibo Chen, Xiaoxia Chen, Yulun Gu, Yongqi Jiang, Hongzhi Guo, Jinyu Chen, Jun Yu, Chen Wang, Chao Chen and Hui Li

Science of The Total Environment, 2024, 949, 175132
DOI: 10.1016/j.scitotenv.2024.175132

Dual modulation of gut bacteria and fungi manifests the gut-based anti-hyperlipidemic effect of Coptidis Rhizoma

Yanan Yang, Shijie Cao, Wenyi Xu, Chenchen Zang, Fang Zhang, Yong Xie and Chongming Wu

Biomedicine & Pharmacotherapy, 2022, 153, 113542
DOI: 10.1016/j.biopha.2022.113542

Food Contamination with Micro-plastics: Occurrences, Bioavailability, Human Vulnerability, and Prevention

Nunna Sai Venkata Lakshmayya, Ashoutosh Panday, Rajasri Yadavalli, Chintakunta Nagendranatha Reddy, Sanjeeb Kumar Mandal, Dinesh Chand Agrawal and Bishwambhar Mishra

CNF, 2024, 20, 797
DOI: 10.2174/1573401319666230915164116

Ingested nano- and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body

Marlene Schwarzfischer, Anna Niechcial, Sung Sik Lee, Brian Sinnet, Marcin Wawrzyniak, Andrea Laimbacher, Kirstin Atrott, Roberto Manzini, Yasser Morsy, Janine Häfliger, Silvia Lang, Gerhard Rogler, Ralf Kaegi, Michael Scharl and Marianne R. Spalinger

NanoImpact, 2022, 25, 100374
DOI: 10.1016/j.impact.2021.100374

Effects of microplastics and tetracycline on intestinal injury in mice

Lixin Wang, Jiamin Chen, Xuan Zhang, Man Xu, Xuyan Zhang, Wanqing Zhao and Jiansheng Cui

Chemosphere, 2023, 337, 139364
DOI: 10.1016/j.chemosphere.2023.139364

Maternal microplastic exposure during pregnancy and risk of gestational diabetes mellitus associated with gut dysbiosis

Deboral Panneerselvam and Anuradha Murugesan

Medicine in Microecology, 2023, 18, 100091
DOI: 10.1016/j.medmic.2023.100091

Describing the Accumulation, Concentration, and Amplification Effects of MPs Through the Food Chain

Ulku Dagdelen, Dogan Turkyilmaz and Nurinisa Esenbuga

CNF, 2025, 21, 430
DOI: 10.2174/0115734013321875240913043337

Toxic Effects of Xenobiotics on Gut Microbiome and Host Health: A Mini-Review

Anshupriya Shome

TI, 2024, 1
DOI: 10.18311/ti/2025/v32i1/45370

Neurotoxicity Following Exposure to Micro and Nanoplastics

Mojtaba Ehsanifar and Zeinab Yavari

OBM Neurobiol, 2025, 09, 1
DOI: 10.21926/obm.neurobiol.2501277

Ingested Polystyrene Microplastics as a Carrier of Heavy Metals (Cadmium or Silver): Uptake, Gut Damage, Oxidative Stress, and DNA Damage In Drosophila Larvae

Esref Demir, Fatma Turna Demir and Gökhan Akkoyunlu

SSRN Journal, 2022
DOI: 10.2139/ssrn.4130894

A Systematic Review of the Toxicokinetics of Micro- and Nanoplastics in Mammals Following Digestive Exposure

Raluca Paula Popa and Alexandru Flaviu Tabaran

Applied Sciences, 2025, 15, 6135
DOI: 10.3390/app15116135

Early enteric and hepatic responses to ingestion of polystyrene nanospheres from water in C57BL/6 mice

Joseph A. Szule, Lawrence R. Curtis, Thomas J. Sharpton, Christiane V. Löhr, Susanne M. Brander, Stacey L. Harper, Jamie M. Pennington, Sara J. Hutton, Michael J. Sieler and Kristin D. Kasschau

Front. Water, 2022, 4
DOI: 10.3389/frwa.2022.925781

Environmental Health and Safety Implications of the Interplay Between Microplastics and the Residing Biofilm

Xiaohan Wu, Fei He, Xueran Xu, Leilei Wu, Jinyu Rong and Sijie Lin

Environ. Health, 2025, 3, 118
DOI: 10.1021/envhealth.4c00148

Polystyrene nanoplastics induced lung injury in mice: Insights into lung metabolic disorders

Zhe Wang, Ning Wang, Shuo Jiang, Runyan Shi, Ruimin Wang and Weidong Wu

Ecotoxicology and Environmental Safety, 2025, 303, 119060
DOI: 10.1016/j.ecoenv.2025.119060

Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans

Yunjiang Yu, Dongli Xie, Yue Yang, Shihui Tan, Hongyan Li, Yao Dang, Mingdeng Xiang and Haibo Chen

Journal of Hazardous Materials, 2023, 445, 130543
DOI: 10.1016/j.jhazmat.2022.130543

Microplastics/nanoplastics contribute to aging and age-related diseases: Mitochondrial dysfunction as a crucial role

Liang Kong, Shuhao Li, Yu Fu, Qinyun Cai, Zhengyu Zhai, Jingyan Liang and Tan Ma

Food and Chemical Toxicology, 2025, 199, 115355
DOI: 10.1016/j.fct.2025.115355

Impacts of polystyrene nanoplastics at the environmentally relevant and sub-lethal concentrations on the oxidative stress, immune responses, and gut microbiota to grass carp (Ctenopharyngodon idella)

Zhen Li, Lei Yan, Muhammad Junaid, Xikun Chen, Hongping Liao, Dandan Gao, Qiuping Wang, Yanling Zhang and Jun Wang

Journal of Hazardous Materials, 2023, 441, 129995
DOI: 10.1016/j.jhazmat.2022.129995

Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model

Davood Kharaghani, Glen M. DeLoid, Trung Huu Bui, Nubia Zuverza-Mena, Carlos Tamez, Craig Musante, Jason C. White and Philip Demokritou

Microplastics, 2025, 4, 4
DOI: 10.3390/microplastics4010004

Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective

Shoumi Haldar, Yuvashree Muralidaran, Diana Míguez, Sikandar I. Mulla and Prabhakar Mishra

Science of The Total Environment, 2023, 861, 160571
DOI: 10.1016/j.scitotenv.2022.160571

Disease-specific protein corona formed in pathological intestine enhances the oral absorption of nanoparticles

Jiawei Wu, Liyun Xing, Yaxian Zheng, Yinglan Yu, Ruinan Wu, Xi Liu, Lian Li and Yuan Huang

Acta Pharmaceutica Sinica B, 2023, 13, 3876
DOI: 10.1016/j.apsb.2023.02.012

Quercetin protects against hyperglycemia-induced retinopathy in Sprague Dawley rats by regulating the gut-retina axis and nuclear factor erythroid-2–related factor 2 pathway

Yaojie Liu, Yibo Gong, Mengting Li and Jianke Li

Nutrition Research, 2024, 122, 55
DOI: 10.1016/j.nutres.2023.12.003

Harmful effects of the microplastic pollution on animal health: a literature review

Natalia Zolotova, Anna Kosyreva, Dzhuliia Dzhalilova, Nikolai Fokichev and Olga Makarova

PeerJ, 2022, 10, e13503
DOI: 10.7717/peerj.13503

Polystyrene microplastics induce molecular toxicity in Simocephalus vetulus: A transcriptome and intestinal microorganism analysis

Chenxi Zhu, Hui Zhou, Mengyu Bao, Shengkai Tang, Xiankun Gu, Mingming Han, Peng Li and Qichen Jiang

Aquatic Toxicology, 2024, 275, 107046
DOI: 10.1016/j.aquatox.2024.107046

From insects to mammals! Tissue accumulation and transgenerational transfer of micro/nano-plastics through the food chain

Yijing Wang, Xinrui Nan, Huayang Sun, Yutian Shi, Jixing Miao, Yuheng Li, Xiaoyu Han, Ning Zhang, Huaqin Wang, Nanqi Ren, Xin Zhao and Baoqin Liu

Journal of Hazardous Materials, 2024, 480, 136424
DOI: 10.1016/j.jhazmat.2024.136424

Emerging applications of postbiotics to sustainable livestock production systems

John R. Otto, Felista W. Mwangi, Shedrach B. Pewan, Benjamin W.B. Holman and Aduli E.O. Malau-Aduli

Aust J Agric Vet Anim Sci (AJAVAS), 2025, 1, 100002
DOI: 10.64902/ajavas.2025.100002

Local and systemic effects of microplastic particles through cell damage, release of chemicals and drugs, dysbiosis, and interference with the absorption of nutrients

Eleonore Fröhlich

Journal of Toxicology and Environmental Health, Part B, 2024, 27, 315
DOI: 10.1080/10937404.2024.2406192

Coptis chinensis shows distinct effects on hyperlipidemia and gut microbiota in high-fat diet induced mice with cold or hot syndrome

Yanan Yang, Jiaguo Zhan, Jiale Cheng, Ying Cao and Chongming Wu

Chinese Herbal Medicines, 2025, 17, 529
DOI: 10.1016/j.chmed.2025.04.009

Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption

Ville M Koistinen, Ambrin Farizah Babu, Ehsan Shad and Iman Zarei

F, 2025, 4, 238
DOI: 10.48130/fia-0025-0022

Microbial risks associated with microplastics in the food chain and possible control measures (literature review). Part 1. Dietary intake and influence on the gut microbiota

Svetlana A. Sheveleva, Yulia M. Markova, Natalya R. Efimochkina, Lyudmila P. Minaeva, Irina B. Bykova, Elena E. Zinurova, Yulia V. Smotrina, Anna S. Polyanina, Valentina V. Stetsenko and Sergey A. Khotimchenko

Hygiene and sanitation, 2023, 102, 1334
DOI: 10.47470/0016-9900-2023-102-12-1334-1347

Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure

Manjyot Kaur, Anju Sharma, Kirti Sharma, Placheril John and Pradeep Bhatnagar

Toxicology, 2025, 511, 154043
DOI: 10.1016/j.tox.2024.154043

Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway

Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu and Fen Fu

Ecotoxicology and Environmental Safety, 2025, 290, 117622
DOI: 10.1016/j.ecoenv.2024.117622

Long-term exposure to polystyrene microplastics triggers premature testicular aging

Deyi Wu, Meng Zhang, Ting Ting Bao and Hainan Lan

Part Fibre Toxicol, 2023, 20
DOI: 10.1186/s12989-023-00546-6

Effects of Polyvinyl Chloride Microplastics on the Reproductive System, Intestinal Structure, and Microflora in Male and Female Mice

Yang-Kai-Xin Yang, Shu-Jun Ge, Qi-Ling Su, Jin-Jun Chen, Jiang Wu and Kai Kang

Veterinary Sciences, 2024, 11, 488
DOI: 10.3390/vetsci11100488

Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

Diqi Yang, Jiandi Zhu, Xiaoshu Zhou, Di Pan, Sha Nan, Ruiling Yin, Qianghui Lei, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding and Yi Ding

Environment International, 2022, 166, 107362
DOI: 10.1016/j.envint.2022.107362

Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice

Hua Zha, Ruiqi Tang, Shengjie Li, Aoxiang Zhuge, Jiafeng Xia, Jiawen Lv, Shuting Wang, Kaiceng Wang, Hua Zhang and Lanjuan Li

Chemosphere, 2024, 349, 140940
DOI: 10.1016/j.chemosphere.2023.140940

The effects of temperature on the nutritional quality of crayfish (Procambarus clarkii) were analyzed by combining transcriptome, metabolome and intestinal microbiota

Ruichun Li, Wenqi Qian, Li Huang, Shuyan Bai, Chenhui Li, Ningning Du, Long Cheng, Lei Xiu, Linhai Yu, Tao Guan, Jian Li, Shilong Chen, Dongli Qin and Lei Gao

Food Bioscience, 2025, 71, 107176
DOI: 10.1016/j.fbio.2025.107176

Assessing micro and nanoplastics toxicity using rodent models: Investigating potential mitochondrial implications

Mónica G. Silva, Maria Manuel Oliveira and Francisco Peixoto

Toxicology, 2023, 499, 153656
DOI: 10.1016/j.tox.2023.153656

Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn’s disease human duodenum-chip models

Davood Kharaghani, Glen M. DeLoid, Ping He, Ben Swenor, Trung Huu Bui, Nubia Zuverza-Mena, Carlos Tamez, Craig Musante, Michael Verzi, Jason C. White and Philip Demokritou

Journal of Hazardous Materials, 2025, 490, 137714
DOI: 10.1016/j.jhazmat.2025.137714

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

Huixia Niu, Shaojie Liu, Yujie Jiang, Yang Hu, Yahui Li, Luyang He, Mingluan Xing, Xueqing Li, Lizhi Wu, Zhijian Chen, Xiaofeng Wang and Xiaoming Lou

Metabolites, 2023, 13, 739
DOI: 10.3390/metabo13060739

Impact of Nanoplastic Particles on Macrophage Inflammation and Intestinal Health in a Mouse Model of Inflammatory Bowel Disease

Marlene Schwarzfischer, Tano S. Ruoss, Anna Niechcial, Sung Sik Lee, Marcin Wawrzyniak, Andrea Laimbacher, Kirstin Atrott, Roberto Manzini, Marijn Wilmink, Luise Linzmeier, Yasser Morsy, Silvia Lang, Gerhard Rogler, Ralf Kaegi, Michael Scharl and Marianne R. Spalinger

Nanomaterials, 2024, 14, 1350
DOI: 10.3390/nano14161350

Micro- and Nanoplastics and the Oral Cavity: Implications for Oral and Systemic Health, Dental Practice, and the Environment—A Narrative Review

Federica Di Spirito, Veronica Folliero, Maria Pia Di Palo, Giuseppina De Benedetto, Leonardo Aulisio, Stefano Martina, Luca Rinaldi and Gianluigi Franci

JFB, 2025, 16, 332
DOI: 10.3390/jfb16090332

Micro(nano)plastics in food system: potential health impacts on human intestinal system

Siyue Wen, Yu Zhao, Mengqi Wang, Hongbin Yuan and Hengyi Xu

Critical Reviews in Food Science and Nutrition, 2024, 64, 1429
DOI: 10.1080/10408398.2022.2116559

Interfacial effects of perfluorooctanoic acid and its alternative hexafluoropropylene oxide dimer acid with polystyrene nanoplastics on oxidative stress, histopathology and gut microbiota in Crassostrea hongkongensis oysters

Bin Wang, Muhammad Junaid, Guanglong Chen and Jun Wang

Science of The Total Environment, 2024, 932, 172864
DOI: 10.1016/j.scitotenv.2024.172864

Simulated Microplastic Release from Cutting Boards and Evaluation of Intestinal Inflammation and Gut Microbiota in Mice

Hai-Jun Gan, Shan Chen, Ke Yao, Xin-Ying Lin, Albert L. Juhasz, Dongmei Zhou and Hong-Bo Li

Environ Health Perspect, 2025, 133
DOI: 10.1289/EHP15472

Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolites

Wen Chen, Pengcheng Tu, Xiang Ye, Qiong Tang, Ting Yu and Xiaodong Zheng

Toxicology and Applied Pharmacology, 2022, 453, 116212
DOI: 10.1016/j.taap.2022.116212

The lull before microplastics pollution outbreaks: Some implications for human health and control strategies

Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu and Ying Liu

Nano Today, 2024, 54, 102062
DOI: 10.1016/j.nantod.2023.102062

Potential Biological Impacts of Microplastics and Nanoplastics on Farm Animals: Global Perspectives with Insights from Bangladesh

FNU Nahiduzzaman, Md Zaminur Rahman, Mst. Arjina Jannat Akhi, Mohammed Manik, Mst Minara Khatun, Md. Ariful Islam, Mohammad Nurul Matin and Md Azizul Haque

Animals, 2025, 15, 1394
DOI: 10.3390/ani15101394

Effects of polystyrene nanoplastics (PSNPs) on the physiology and molecular metabolism of corn (Zea mays L.) seedlings

Yu Zhang, Xu Yang, Zhong-xu Luo, Jin-long Lai, Chen Li and Xue-gang Luo

Science of The Total Environment, 2022, 806, 150895
DOI: 10.1016/j.scitotenv.2021.150895

Interactions of Ingested Polystyrene Microplastics with Heavy Metals (Cadmium or Silver) as Environmental Pollutants: A Comprehensive In Vivo Study Using Drosophila melanogaster

Fatma Turna Demir, Gökhan Akkoyunlu and Eşref Demir

Biology, 2022, 11, 1470
DOI: 10.3390/biology11101470

Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice

Xuanwei Chen, Yang Xuan, Yawen Chen, Fanfan Yang, Mengying Zhu, Jian Xu and Jin Chen

Science of The Total Environment, 2024, 935, 173458
DOI: 10.1016/j.scitotenv.2024.173458

Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis

Natalia Zolotova, Dzhuliia Dzhalilova, Ivan Tsvetkov and Olga Makarova

Toxics, 2023, 11, 730
DOI: 10.3390/toxics11090730

Multiomics analysis reveals the molecular basis for increased body weight in silkworms (Bombyx mori) exposed to environmental concentrations of polystyrene micro- and nanoplastics

Abrar Muhammad, Nan Zhang, Jintao He, Xiaoqiang Shen, Xinyue Zhu, Jian Xiao, Zhaoyi Qian, Chao Sun and Yongqi Shao

Journal of Advanced Research, 2024, 57, 43
DOI: 10.1016/j.jare.2023.09.010

Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety

Jinyi Wang and Tingting Zhou

Medicinal Research Reviews, 2025, 45, 311
DOI: 10.1002/med.22077

Impacts of microplastics on immunity

Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen and Yang Li

Front. Toxicol., 2022, 4
DOI: 10.3389/ftox.2022.956885

Environmental Microplastic Exposure Changes Gut Microbiota in Chickens

Wen Zou, Sijia Lu, Jia Wang, Yixiao Xu, Muhammad Akbar Shahid, Muhammad Usman Saleem, Khalid Mehmood and Kun Li

Animals, 2023, 13, 2503
DOI: 10.3390/ani13152503

Polystyrene nanoparticles induced mammalian intestine damage caused by blockage of BNIP3/NIX-mediated mitophagy and gut microbiota alteration

Yilun Zhang, Zhenzhen Jia, Xianlei Gao, Juan Zhao and Hongyan Zhang

Science of The Total Environment, 2024, 907, 168064
DOI: 10.1016/j.scitotenv.2023.168064

The Impact of Microplastics on Allergy: Current Status and Future Research Directions

Jia-qian Hu, Yang Zheng and Ya-dong Gao

Int Arch Allergy Immunol, 2025, 1
DOI: 10.1159/000547873

Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts

Ajmal Khan and Zhenquan Jia

iScience, 2023, 26, 106061
DOI: 10.1016/j.isci.2023.106061

Exposure to polystyrene nanoplastics and PCB77 induced oxidative stress, histopathological damage and intestinal microbiota disruption in white hard clam Meretrix lyrata

Chunmiao Kong, Ting Pan, Xikun Chen, Muhammad Junaid, Hongping Liao, Dandan Gao, Qiuping Wang, Wanjing Liu, Xu Wang and Jun Wang

Science of The Total Environment, 2023, 905, 167125
DOI: 10.1016/j.scitotenv.2023.167125

Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review

Yanan Xu, Ling Liu, Yuqing Ma, Cunlong Wang, Fengshang Duan, Jianxue Feng, Haiyang Yin, Le Sun, Zhihan Cao, Jinho Jung, Ping Li and Zhi-Hua Li

Aquatic Toxicology, 2025, 279, 107215
DOI: 10.1016/j.aquatox.2024.107215

Unraveling the micro- and nanoplastic predicament: A human-centric insight

Sybren De Boever, Lindsey Devisscher and Mathieu Vinken

Science of The Total Environment, 2024, 916, 170262
DOI: 10.1016/j.scitotenv.2024.170262

Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity

Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen and Qing Wang

Environmental Pollution, 2023, 330, 121808
DOI: 10.1016/j.envpol.2023.121808

From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies

Xusheng Dong, Xinbei Liu, Qiuling Hou and Zhonghua Wang

Science of The Total Environment, 2023, 855, 158686
DOI: 10.1016/j.scitotenv.2022.158686

Multi-omics reveals 2-bromo-4,6-dinitroaniline (BDNA)-induced hepatotoxicity and the role of the gut-liver axis in rats

Fuchang Deng, Guangqiu Qin, Yuanyuan Chen, Xu Zhang, Mu Zhu, Min Hou, Qiao Yao, Wen Gu, Chao Wang, Hui Yang, Xudong Jia, Chongming Wu, Hui Peng, Huamao Du and Song Tang

Journal of Hazardous Materials, 2023, 457, 131760
DOI: 10.1016/j.jhazmat.2023.131760

Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review

Carlo Covello, Federica Di Vincenzo, Giovanni Cammarota and Marco Pizzoferrato

CIMB, 2024, 46, 2658
DOI: 10.3390/cimb46030168

Micro- and nanoplastics differ in particle-mucus interactions: The sight on rheological properties, barrier dysfunction and microbiota dysbiosis

Xuemei Meng, Xue Zheng, Wenting Mai, Jianying Gao, Yanli Fan, Jing Fu and Junnan Xu

Journal of Hazardous Materials, 2025, 492, 138130
DOI: 10.1016/j.jhazmat.2025.138130

Human Exposure to Microplastics and Its Associated Health Risks

Anqi Sun and Wen-Xiong Wang

Environ. Health, 2023, 1, 139
DOI: 10.1021/envhealth.3c00053

The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression

Ya-Nan Yang, Qing-Chun Wang, Wenyi Xu, Jiaqi Yu, Huricha Zhang and Chongming Wu

Biomedicine & Pharmacotherapy, 2022, 155, 113749
DOI: 10.1016/j.biopha.2022.113749

Effect of nano- and micro-polystyrene particles on small intestinal epithelial functions and enteric neuronal activity in vitro

Kristin Elfers, Pascal Benz, Marion Burmester, Silja Hein, Kathrin Hansen, Holger Sieg, Linda Böhmert, Maxi B. Paul and Gemma Mazzuoli-Weber

Micropl.&Nanopl., 2025, 5
DOI: 10.1186/s43591-025-00110-3

Polystyrene microplastic‐induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat

Qingqing Zhang, Yuanyuan Lang, Xiaomin Tang, Wenshu Cheng, Zugen Cheng, Mohammad Rizwan, Lixin Xie, Yanling Liu, Hengyi Xu and Yang Liu

Environmental Toxicology, 2024, 39, 3314
DOI: 10.1002/tox.24182

Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats

Walaa Bayoumie El Gazzar, Rania E. Sliem, Heba Bayoumi, Hend Elsayed Nasr, Manar Shabanah, Amira Elalfy, Shaimaa E. Radwaan, Mohammed A. Gebba, Heba M. Mansour, Amul M. Badr, Marwa Fathy Amer, Sara S. Ashour, Heba Morsi, El Shaimaa Ahmed Fahmy Aboelkomsan, Bodour Baioumy, Alaa El-Din Hamid Sayed and Amina A. Farag

IJMS, 2023, 24, 13619
DOI: 10.3390/ijms241713619

The role of gut microbiota in MP/NP-induced toxicity

Yinping Pan, Haojie Zhang, Liancai Zhu, Jun Tan, Bochu Wang and Minghui Li

Environmental Pollution, 2024, 359, 124742
DOI: 10.1016/j.envpol.2024.124742

Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances

Haonan Zhao, Guo Lin, Yuhang Yin, Qinke Wu, Yan Wang, Ning Tang and Xingshun Qi

European Journal of Internal Medicine, 2025, 139, 106419
DOI: 10.1016/j.ejim.2025.07.015

Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides

Hongping Liao, Shulin Liu, Muhammad Junaid, Dandan Gao, Wenjie Ai, Guanglong Chen and Jun Wang

Water Research, 2022, 219, 118608
DOI: 10.1016/j.watres.2022.118608

A review of potential human health impacts of micro- and nanoplastics exposure

Jun-Li Xu, Xiaohui Lin, Jing Jing Wang and Aoife A. Gowen

Science of The Total Environment, 2022, 851, 158111
DOI: 10.1016/j.scitotenv.2022.158111

Salt-contaminated water exposure induces gut microbial dysbiosis in chickens

Aoyun Li, Zhigao An, Caiyue Li, Xuejie Cui, Kun Li, Hui Zhou, Bingxue Zhou, Ping Hao, Md. F Kulyar, Wen Yin, Xin Wan, Liangliang Li, Zhaojing Luo, Muhammad Waqar Hassan and Yi Wu

Ecotoxicology and Environmental Safety, 2023, 254, 114731
DOI: 10.1016/j.ecoenv.2023.114731

The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet

Marlene Schwarzfischer and Gerhard Rogler

Metabolites, 2022, 12, 223
DOI: 10.3390/metabo12030223

Engineered biocorona on microplastics as a toxicity mitigation strategy in marine environment: Experiments with a marine crustacean Artemia salina

Camil Rex M, Anushka Bairoliya, Shristi Gairola, Pooja Sureshkumar, Vidya Niranjan, Anish Nag and Amitava Mukherjee

Journal of Hazardous Materials Advances, 2025, 17, 100558
DOI: 10.1016/j.hazadv.2024.100558

Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs

Zhenning Yang, Glen M. DeLoid, Helmut Zarbl, Joshua Baw and Philip Demokritou

NanoImpact, 2023, 32, 100481
DOI: 10.1016/j.impact.2023.100481

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Alexandria Ruggles and Corinne Benakis

Cells, 2024, 13, 803
DOI: 10.3390/cells13100803

Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)

Li Zhou, Lidan Ran, Yufen He and Yaxi Huang

Mol Med Rep, 2025, 31, 1
DOI: 10.3892/mmr.2025.13463

The impact of engineered nanomaterials on the environment: Release mechanism, toxicity, transformation, and remediation

C.M. Vineeth Kumar, V. Karthick, V. Ganesh Kumar, D. Inbakandan, Eldon R. Rene, K.S. Uma Suganya, Asha Embrandiri, T. Stalin Dhas, M. Ravi and P. Sowmiya

Environmental Research, 2022, 212, 113202
DOI: 10.1016/j.envres.2022.113202

Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications

Saurabh Shukla, Sakshum Khanna and Kushagra Khanna

Toxicology Reports, 2025, 14, 101844
DOI: 10.1016/j.toxrep.2024.101844

Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs

Wei-Hsuan Hsu, You-Zuo Chen, Yi-Ting Chiang, Yi-Tsen Chang, Yi-Wen Wang, Kung-Ting Hsu, Yi-Yun Hsu, Pei-Ting Wu and Bao-Hong Lee

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-59884-y

Penetration of micro/nanoplastics into biological barriers in organisms and associated health effects

Hao Qiu, Jingjing Li, Guangquan Chen, Tianyi Cao, Jing Li, Xing Li and Rongliang Qiu

Chin. Sci. Bull., 2023
DOI: 10.1360/TB-2023-0295

Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics

Hua Zha, Shengyi Han, Ruiqi Tang, Dan Cao, Kevin Chang and Lanjuan Li

Environmental Science and Ecotechnology, 2024, 21, 100428
DOI: 10.1016/j.ese.2024.100428

Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?

Javad Bazeli, Zarrin Banikazemi, Michael R. Hamblin and Reza Sharafati Chaleshtori

Front. Nutr., 2023, 10
DOI: 10.3389/fnut.2023.1186724

Micro- and Nanoplastics as Emerging Threats to Both Terrestrial and Aquatic Animals: A Comprehensive Review

Munwar Ali, Chang Xu and Kun Li

Veterinary Sciences, 2025, 12, 688
DOI: 10.3390/vetsci12080688

Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dysfunction via the NF-κB/NLRP3/IL-1β/MCLK pathway

Guodong Zeng, Jingyi Li, Yuanli Wang, Jingran Su, Zhongbing Lu, Fang Zhang and Wenjun Ding

Environmental Pollution, 2024, 345, 123473
DOI: 10.1016/j.envpol.2024.123473

Alterations of gut and oral microbiota in the individuals consuming take-away food in disposable plastic containers

Hua Zha, Jiawen Lv, Yiqing Lou, Wanlong Wo, Jiafeng Xia, Shengjie Li, Aoxiang Zhuge, Ruiqi Tang, Nian Si, Zhihao Hu, Haifeng Lu, Kevin Chang, Chenyu Wang, Guinian Si and Lanjuan Li

Journal of Hazardous Materials, 2023, 441, 129903
DOI: 10.1016/j.jhazmat.2022.129903

Characterization of airborne microplastics at different workplaces of the poly(ethylene:propylene:diene) (EPDM) rubber industry

Xiaoni Sun, Rong Song, Jintao Liu, Shuangshuang Yan, Yuxuan Li, Xiaoyu Jin, Yunfeng Liang, Yudong Wu, Lu Mei, Rubing Pan, Weizhuo Yi, Jian Song, Jian Cheng and Hong Su

Environ Sci Pollut Res, 2023, 30, 78839
DOI: 10.1007/s11356-023-27750-3

Understanding the implications of microplastics on maternal health during pregnancy, gut dysbiosis, and gestational diabetes mellitus

Sriram Seshadri

JRHM, 2025, 6, 15
DOI: 10.25259/JRHM_17_2025

The microplastics exposure induce the kidney injury in mice revealed by RNA-seq

Xi Xiong, Likun Gao, Chen Chen, Kai Zhu, Pengcheng Luo and Lili Li

Ecotoxicology and Environmental Safety, 2023, 256, 114821
DOI: 10.1016/j.ecoenv.2023.114821

Polystyrene microplastics induced nephrotoxicity associated with oxidative stress, inflammation, and endoplasmic reticulum stress in juvenile rats

Wanzhen Wang, Jiafu Guan, Yueying Feng, Liju Nie, Yuanyuan Xu, Hengyi Xu and Fen Fu

Front. Nutr., 2023, 9
DOI: 10.3389/fnut.2022.1059660

Cellular absorption of polystyrene nanoplastics with different surface functionalization and the toxicity to RAW264.7 macrophage cells

Jiao Chen, Zijun Xu, Yuying Liu, AoXue Mei, Xiyuan Wang and Qingdong Shi

Ecotoxicology and Environmental Safety, 2023, 252, 114574
DOI: 10.1016/j.ecoenv.2023.114574

Polystyrene microplastics trigger colonic inflammation in rats via the TLR4/NF-κB/COX-2 pathway and modulation of intestinal microbiota

Xuemin Feng, Meng Zhang, Tianyang Zhao, Jianwei Cui, Hui Ye, Chunkui Zhou, Lin Ye and Liting Zhou

Toxicology, 2025, 513, 154090
DOI: 10.1016/j.tox.2025.154090

Effects of microplastics in aquatic environments on inflammatory bowel disease

Jiali Ji, Xinyue Wu, Xi Li and Ya Zhu

Environmental Research, 2023, 229, 115974
DOI: 10.1016/j.envres.2023.115974

Oral exposure to nano- and microplastics: Potential effects in food allergies?

Qiang Shi, Zhongliang Wang, Yong Wu, Hongbing Chen and Jinyan Gao

Allergy Medicine, 2024, 1, 100006
DOI: 10.1016/j.allmed.2024.100006

Determination of no observable effect level of nanoplastics on intestinal flora

Zhen Zhang, Juan Zhao, Zhenzhen Jia and Hongyan Zhang

Chemosphere, 2023, 344, 140327
DOI: 10.1016/j.chemosphere.2023.140327

The impact of microplastics polystyrene on the microscopic structure of mouse intestine, tight junction genes and gut microbiota

Qi-Ling Su, Jiang Wu, Shao-Wen Tan, Xiao-Yun Guo, Ding-Zhe Zou, Kai Kang and Birendra Mishra

PLoS ONE, 2024, 19, e0304686
DOI: 10.1371/journal.pone.0304686

Aging of Nanoplastics Significantly Affects Protein Corona Composition Thus Enhancing Macrophage Uptake

Tingting Du, Xiang Yu, Song Shao, Tong Li, Shengmin Xu and Lijun Wu

Environ. Sci. Technol., 2023, 57, 3206
DOI: 10.1021/acs.est.2c05772

Foodborne and airborne polyethersulfone nanoplastics respectively induce liver and lung injury in mice: Comparison with microplastics

Hua Zha, Jiafeng Xia, Kaicen Wang, Lvwan Xu, Kevin Chang and Lanjuan Li

Environment International, 2024, 183, 108350
DOI: 10.1016/j.envint.2023.108350

Fate and impact of nanoplastics in the human digestive environment after oral exposure: A common challenge for toxicology and chemistry

Chloé Liebgott, Iseline Chaib, Périne Doyen, Hervé Robert, Hélène Eutamene, Guillaume Duflos, Stéphanie Reynaud, Bruno Grassl and Muriel Mercier-Bonin

TrAC Trends in Analytical Chemistry, 2023, 166, 117175
DOI: 10.1016/j.trac.2023.117175