Covalent binding of flucloxacillin to 14-3-3 proteins promotes naive T-cell activation

Georgia Wells, Sophie Grice, Joscelyn Sarsby, Dean Naisbitt and Xiaoli Meng

Journal of Allergy and Clinical Immunology, 2026, 157, 996
DOI: 10.1016/j.jaci.2026.01.007

A central chaperone-like role for 14-3-3 proteins in human cells

Dmitri Segal, Stefan Maier, Giovanni J. Mastromarco, Wesley Wei Qian, Syed Nabeel-Shah, Hyunmin Lee, Gaelen Moore, Jessica Lacoste, Brett Larsen, Zhen-Yuan Lin, Abeeshan Selvabaskaran, Karen Liu, Craig Smibert, Zhaolei Zhang, Jack Greenblatt, Jian Peng, Hyun O. Lee, Anne-Claude Gingras and Mikko Taipale

Molecular Cell, 2023, 83, 974
DOI: 10.1016/j.molcel.2023.02.018

Recent Developments in 14–3–3 Stabilizers for Regulating Protein–Protein Interactions: An Update

Yucheng Tian, Longjing Li, Liuyi Wu, Qianqian Xu, Yaojie Li, Huawei Pan, Tiejun Bing, Xiumei Bai, Alexander V Finko, Zhiyu Li and Jinlei Bian

J. Med. Chem., 2025, 68, 2124
DOI: 10.1021/acs.jmedchem.4c01936

Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson’s disease: a patent review of the literature to date

Margaux Morez, Antonio Jesús Lara Ordóñez, Patricia Melnyk, Maxime Liberelle, Nicolas Lebègue and Jean-Marc Taymans

Expert Opinion on Therapeutic Patents, 2024, 34, 773
DOI: 10.1080/13543776.2024.2378076

Molecular glues: enhanced protein-protein interactions and cell proteome editing

Evita G. Weagel, Jason M. Foulks, Adam Siddiqui and Steven L. Warner

Med Chem Res, 2022, 31, 1068
DOI: 10.1007/s00044-022-02882-2

Stabilization of Native Protein–Protein Interactions with Molecular Glues: A 14-3-3 Case Study

Markella Konstantinidou, Johanna M. Virta and Michelle R. Arkin

Acc. Chem. Res., 2025, 58, 2840
DOI: 10.1021/acs.accounts.5c00441

Contemporary biophysical approaches for studying 14-3-3 protein-protein interactions

Bethany Thurairajah, Andrew J. Hudson and Richard G. Doveston

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.1043673

Molecular glues evolve from serendipity to rational design

Princy Shrivastav, Rohit Singh and Andrew J. Wiemer

Trends in Pharmacological Sciences, 2026, 47, 85
DOI: 10.1016/j.tips.2025.10.013

The Function of Lymphocyte Cytoplasmic Protein 2 and Its Research Progress in Malignant Tumors

静陈

ACM, 2023, 13, 5494
DOI: 10.12677/ACM.2023.134777

A Novel Confocal Scanning Protein–Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin

Joanna Koszela, Nhan T. Pham, Steven Shave, Daniel St-Cyr, Derek F. Ceccarelli, Steven Orlicky, Anne Marinier, Frank Sicheri, Mike Tyers and Manfred Auer

Bioconjugate Chem., 2024, 35, 1441
DOI: 10.1021/acs.bioconjchem.4c00345

Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains

Rohit Joshi, Pavel Pohl, Dita Strachotova, Petr Herman, Tomas Obsil and Veronika Obsilova

Biophysical Journal, 2022, 121, 1299
DOI: 10.1016/j.bpj.2022.02.025

Molecular glues to stabilise protein–protein interactions

Lorenzo Soini, Seppe Leysen, Jeremy Davis and Christian Ottmann

Current Opinion in Chemical Biology, 2022, 69, 102169
DOI: 10.1016/j.cbpa.2022.102169

Molecular glues for protein-protein interactions: Progressing toward a new dream

Markella Konstantinidou and Michelle R. Arkin

Cell Chemical Biology, 2024, 31, 1064
DOI: 10.1016/j.chembiol.2024.04.002

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston and Aneika C. Leney

Advanced Science, 2025, 12
DOI: 10.1002/advs.202508543