Antiproliferative activity of berberine in HepG2 cells via inducing apoptosis and arresting cell cycle

Lele Yang, Jiliang Cao, Jinchao Wei, Jiagang Deng, Xiaotao Hou, Erwei Hao, Zhengcai Du, Liang Zou and Peng Li

Food Funct., 2021, 12, 12115
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Gliadin hydrolysates nanoparticles improve the bioavailability and antioxidant activity of berberine

Xiaoxiao Li, Jihong Huang and Rui Tan

Food Chemistry, 2025, 482, 143934
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Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway

Chunbin Sun, Xiaoyu Gao, Shuang Sha, Si Wang, Yubang Shan, Luping Li, Cencan Xing, Hongyan Guan and Hongwu Du

International Immunopharmacology, 2025, 155, 114550
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Lead Phytomolecules for Treating Parkinson’s Disease

Krishn Kumar Agrawal, Chandra Veer, Yogesh Murti and Sunil Pratap Singh

CNSAMC, 2025, 25, 337
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Autophagy in disease management: Exploring the potential of natural products as targeted therapies

Laila A. Eissa, Amani M. Marawan, Mohamed E. Marawan and Shimaa A. Abass

Pathology - Research and Practice, 2025, 272, 156077
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JWH133 attenuates behavior deficits and iron accumulation in 6-OHDA-induced Parkinson’s disease model rats

Man Liu, Dong Pan, MengYa Wang, Han Deng and ZeGang Ma

Journal of Neurophysiology, 2024, 132, 733
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Berberine Improves Depression‐Like Behaviors and Gastrointestinal Dysfunction in 6‐Hydroxydopamine‐Induced Parkinson's Disease Rats

Zi‐Ming Liu, Xiao‐Li Zhang, Yu‐Li Sun, Li‐Fei Zheng, Cai‐Feng Zhang, Xiao Yu, Tian‐Ze Zhang, Jin Song, Yue Zhang and Jin‐Xia Zhu

Neurogastroenterology Motil, 2025, 37
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Neuroprotective effect of the herbal pair Coptidis Rhizoma-Cinnamomi Cortex against 6-OHDA-induced Parkinson's disease rats through promotion of autophagy via the PI3K/AKT/mTOR pathway

Yimeng Zhao, Yuqing Ma, Lijuan Xiong, Jiaxuan Ai, Xing Wang, Xiaoqing Chen, Yaonan Wang, Yinying Ba and Xia Wu

Journal of Ethnopharmacology, 2026, 355, 120582
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Berberine: A Promising Treatment for Neurodegenerative Diseases

Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li and Ranji Cui

Front. Pharmacol., 2022, 13
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Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Tatiana Usenko, Anastasia Bezrukova, Margarita M. Rudenok, Katerina Basharova, Maria I. Shadrina, Petr A. Slominsky, Ekaterina Zakharova and Sofya Pchelina

IJMS, 2023, 24, 12164
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Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

Xu Dong-Chen, Chen Yong, Xu Yang, ShenTu Chen-Yu and Peng Li-Hua

Sig Transduct Target Ther, 2023, 8
DOI: 10.1038/s41392-023-01353-3

Berberine can be a Potential Therapeutic Agent in Treatment of Huntington's Disease: A Proposed Mechanistic Insight

Seema Sharma, Inderpreet Kaur, Naina Dubey, Neelima Goswami and Sampat Singh Tanwar

Mol Neurobiol, 2025
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Parkinson Disease Signaling Pathways, Molecular Mechanisms, and Potential Therapeutic Strategies: A Comprehensive Review

Muhammad S. Khan, Somayyeh Nasiripour and Jean C. Bopassa

IJMS, 2025, 26, 6416
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Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration

Md. Zamshed Alam Begh, Md Al Amin, Mst Maharunnasa Shatu, Sherouk Hussein Sweilam, Sachin Puri, Rathod Bhagyashri Ramesh, Uppuluri Varuna Naga Venkata Arjun, Thukani Sathanantham Shanmugarajan, Nagaveni Pommala, Akiladevi Durairaj, Susithra Ethiraj, Nagarajan Shenbakadurai, Irfan Ahmad and Talha Bin Emran

Chemistry & Biodiversity, 2025, 22
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Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration

Anchal Trisal and Abhishek Kumar Singh

Cell Mol Neurobiol, 2024, 44
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Berberine's paradox in Neurodegeneration: Therapeutic promise and safety challenges in Parkinson's disease

Sultan M. Alshahrani, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Mohamed N. Fawzy, Sultan F. Kadasah, Mubarak Alruwaili, Marios Papadakis, Athanasios Alexiou and Gaber El-Saber Batiha

Neuropharmacology, 2025, 278, 110555
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A Review of the Protective Effects of Alkaloids against Alpha-synuclein Toxicity in Parkinson's Disease

Mahdi Khodadadi and Behjat Javadi

MRMC, 2025, 25, 112
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Targeting Emerging Pathogenic Mechanisms by Natural Molecules as Potential Therapeutics for Neurodegenerative Diseases

Yan Dou and Dongju Zhao

Pharmaceutics, 2022, 14, 2287
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Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms

Jia-Wen Shou and Pang-Chui Shaw

Cells, 2022, 11, 796
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Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells

Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang and Guey-Jen Lee-Chen

Biological & Pharmaceutical Bulletin, 2024, 47, 827
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Neuroprotective efficacy of berberine following developmental exposure to chlorpyrifos in F1 generation of Wistar rats: Apoptosis-autophagy interplay

Era Seth and Mani Chopra

Science of The Total Environment, 2022, 834, 155292
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Can Berberine Serve as a New Therapy for Parkinson’s Disease?

Ehsan Dadgostar, Mahsa Moghanlou, Mehrnoosh Parvaresh, Salimeh Mohammadi, Mohammadali Khandan, Michael Aschner, Hamed Mirzaei and Omid Reza Tamtaji

Neurotox Res, 2022, 40, 1096
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