Issue 26, 2019

Ferritin variants: inspirations for rationally designing protein nanocarriers

Abstract

Ferritin, a natural iron storage protein, is endowed with a unique structure, the ability to self-assemble and excellent physicochemical properties. Beyond these, genetic manipulation can easily tune the structure and functions of ferritin nanocages, which further expands the biomedical applications of ferritin. Here, we focus on human H-ferritin, a recently discovered ligand of transferrin receptor 1, to review its derived variants and related structures and properties. We hope this review will provide new insights into how to rationally design versatile protein cage nanocarriers for effective disease treatment.

Graphical abstract: Ferritin variants: inspirations for rationally designing protein nanocarriers

Article information

Article type
Minireview
Submitted
05 geg. 2019
Accepted
07 birž. 2019
First published
07 birž. 2019

Nanoscale, 2019,11, 12449-12459

Ferritin variants: inspirations for rationally designing protein nanocarriers

Y. Jin, J. He, K. Fan and X. Yan, Nanoscale, 2019, 11, 12449 DOI: 10.1039/C9NR03823J

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