Issue 18, 2012
From the journal:

Journal of Materials Chemistry

The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis†

Demet Goen Colak,a   Ioan Cianga,ab   Dilek Odaci Demirkol,c   Ozge Kozgus,d   E. Ilker Medine,d   Serhan Sakarya,e   Perihan Unak,d   Suna Timur*c  and  Yusuf Yagci*a  

* Corresponding authors

a Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul, Turkey
E-mail: yusuf@itu.edu.tr
Fax: + 90-212-285 6386
Tel: + 90-212-285 3241

b “Petru Poni” Institute of Macromolecular Chemistry, Iasi 700487, Romania

c Biochemistry Department, Faculty of Science, Ege University, Bornova, Izmir, Turkey
E-mail: suna.timur@ege.edu.tr
Fax: +90-232-3438624
Tel: +90-232-3115425

d Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey

e Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University School of Medicine, Aydin, Turkey

Abstract

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

Graphical abstract: The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

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Article information

DOI
https://doi.org/10.1039/C2JM30692A
Article type
Paper
Submitted
05 Feb 2012
Accepted
08 Mar 2012
First published
08 Mar 2012

J. Mater. Chem., 2012,22, 9293-9300

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The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

D. G. Colak, I. Cianga, D. O. Demirkol, O. Kozgus, E. I. Medine, S. Sakarya, P. Unak, S. Timur and Y. Yagci, J. Mater. Chem., 2012, 22, 9293 DOI: 10.1039/C2JM30692A

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