Issue 5, 2019

SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

Abstract

SurE is a new, stand-alone thioesterase (TE) offloading the non-ribosomal peptide (NRP) assembly line found in surugamide biosynthesis. It is homologous to penicillin binding protein (PBP) and capable of cyclizing two structurally unrelated substrates derived from two different NRP assembly lines, highlighting the broad substrate tolerance of the SurE offloading cyclase.

Graphical abstract: SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

  • This article is part of the themed collection: Biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
16 lapkr. 2018
Accepted
04 saus. 2019
First published
05 saus. 2019

Org. Biomol. Chem., 2019,17, 1058-1061

SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

K. Matsuda, M. Kobayashi, T. Kuranaga, K. Takada, H. Ikeda, S. Matsunaga and T. Wakimoto, Org. Biomol. Chem., 2019, 17, 1058 DOI: 10.1039/C8OB02867B

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