Issue 25, 2016

Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy

Abstract

To date, the delivery of nano-sized therapeutic agents to cancers largely relies on enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. However, nano-sized agents delivered in this way have demonstrated limited success in oncology due to the relatively small magnitude of the EPR effect. For achieving superior delivery of nano-sized agents, super-enhanced permeability and retention (SUPR) effects are needed. Near infrared photo-immunotherapy (NIR-PIT) is a recently reported therapy that treats tumors with light therapy and subsequently causes an increase in nano-drug delivery up to 24-fold compared with untreated tumors in which only the EPR effect is present. SUPR effects could enhance delivery into tumor beds of a wide variety of nano-sized agents including particles, antibodies, and protein binding small molecular agents. Therefore, taking advantage of the SUPR effects after NIR-PIT may be a promising avenue to utilize a wide variety of nano-drugs in a highly effective manner.

Graphical abstract: Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy

Article information

Article type
Minireview
Submitted
16 rugp. 2015
Accepted
21 rugs. 2015
First published
30 rugs. 2015

Nanoscale, 2016,8, 12504-12509

Author version available

Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy

H. Kobayashi and P. L. Choyke, Nanoscale, 2016, 8, 12504 DOI: 10.1039/C5NR05552K

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