Issue 11, 2020

Vertically configured nanostructure-mediated electroporation: a promising route for intracellular regulations and interrogations

Abstract

The ability to generate programmable vertically aligned 1D nanoscale substrate topography has spurred advances in five fields of cellular nanotechnology: nanoelectrode-based electrophysiology, intracellular delivery, biosensing, mechanotransduction, and – the focus of this review – understanding the key parameters that govern nanostructure-mediated electroporation for diverse cellular manipulations. The integration of 1D nanostructures into conventional cell manipulation and interrogation systems, based on electroporation, has engendered significant interest over the past decade. We evaluate the latest and most influential studies on engineered nanostructure-mediated electroporation platforms, focusing on the use of tuneable, vertically configured nanostructures – in particular, vertically aligned nanowire, nanostraw, and nanotube arrays – to orchestrate cellular processes such as intracellular delivery, biomolecular extraction, and action potential probing, via both experimental and theoretical studies.

Graphical abstract: Vertically configured nanostructure-mediated electroporation: a promising route for intracellular regulations and interrogations

Article information

Article type
Review Article
Submitted
21 birž. 2020
Accepted
24 rugs. 2020
First published
24 rugs. 2020

Mater. Horiz., 2020,7, 2810-2831

Vertically configured nanostructure-mediated electroporation: a promising route for intracellular regulations and interrogations

A. Shokouhi, S. Aslanoglou, D. Nisbet, N. H. Voelcker and R. Elnathan, Mater. Horiz., 2020, 7, 2810 DOI: 10.1039/D0MH01016B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements