Issue 31, 2019

Nanoparticle-based diagnostic and therapeutic systems for brain tumors

Abstract

Brain tumors, especially the most prevalent and aggressive glioblastoma, remain among the deadliest of all types of cancer due to inefficient theranostic options. They have a limited therapeutic window because of physiological barriers such as the blood–brain barrier (BBB), blood cerebrospinal fluid (CSF) barrier and interstitial fluid (ISF) that restrict the penetration of imaging probes and therapeutic drugs. In order to achieve more accurate brain tumor diagnosis and better therapeutic effects, many strategies have been explored; among them multifunctional nanoparticles offer a novel and potential opportunity depending on their size effects, and their optical, magnetic, photodynamic and other properties. After modification, nanoparticles can cross the BBB and specifically accumulate in the tumor site, thereby achieving accurate tumor imaging and drug release. This review is focused on various types of nanoparticles that are being used for improving nano-carriers of diagnostic and therapeutic agents into brain tumors and also provides a concise summary of various multifunctional theranostic strategies, particularly in clinical applications. In this manner, we provide evidence for the key role of nanoparticle based diagnosis and therapy systems in brain tumors.

Graphical abstract: Nanoparticle-based diagnostic and therapeutic systems for brain tumors

Article information

Article type
Review Article
Submitted
30 bal. 2019
Accepted
03 liep. 2019
First published
09 liep. 2019

J. Mater. Chem. B, 2019,7, 4734-4750

Nanoparticle-based diagnostic and therapeutic systems for brain tumors

X. Wu, H. Yang, W. Yang, X. Chen, J. Gao, X. Gong, H. Wang, Y. Duan, D. Wei and J. Chang, J. Mater. Chem. B, 2019, 7, 4734 DOI: 10.1039/C9TB00860H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements