Themed collection Biomolecular Technologies

We report the development of a chemigenetic fluorescent sodium ion indicator with an affinity optimized for imaging physiologically relevant sodium ion concentrations in mammalian cells.

We developed a nitroreductase-sensitive bioluminescent probe QTZ-NTR. In a breast cancer bone metastasis model, QTZ-NTR detects elevated nitroreductase in hypoxic bone tumors and monitors its dynamic changes during tumor progression.

Antibody and antigen interactions can be used to regulate ferredoxin electron transfer in cells.

Genetically encoded fluorescent sensors have been widely applied to detect cell signaling molecules and events.

This work describes a straightforward strategy for assembling long L-RNAs via the joining of two or more shorter fragments using cross-chiral ligase ribozymes together with new substrate activation chemistry.