Sustainable processes by completing biocatalytic conversions and recovering products completely.
Biocatalysis in flow improves space time yields and enables straightforward downstream processing. The underlying principles of monolithic flow reactors and their application in mono- and bi-phasic biocatalytic systems are discussed.
Publication of the E Factor drew attention to the problem of waste in chemicals manufacture. Thirty yeas later it is abundantly clear that waste is the underlying cause of global environmental problems, from climate change to plastic pollution.
We report a thermally accelerated, air–tolerant Mizoroki–Heck reaction catalyzed by a palladium milling ball. This direct mechanocatalytic approach features facile catalyst recycling, high C(sp2)–I bond selectivity, and operational simplicity.
Two novel dihydroxyacetone-aldolases showcase unique characteristics, distinguishing them from the E. coli counterpart. They enable efficient synthesis of a diverse array of known monosaccharides along with novel compounds previously inaccessible.