A Ru-catalyzed selective hydroacylation of acrylonitriles with aldehydes or alcohols towards β-ketonitriles is established. Glutaronitriles can be obtained through a one-step tandem hydroacylation and Michael addition of acrylonitrile and alcohols.
This review discusses the diverse applications of β-ketonitriles in organic synthesis, highlighting protocols that generate various compounds, including cyclic hydrocarbons, aromatic compounds, heterocycles, spirocycles, and fused heterocycles.
Direct hydroacylation methods for the synthesis of β-ketonitriles from arylacrylonitriles, facilitated by an EDA complex and conducted under room temperature in the absence of light, have been proposed.
Two-component alkene coupling reactions serve as an efficient platform for the synthesis of complex molecular architectures.
A one-pot synthetic strategy to assemble multi-substituted 2,3-dihydrofuran scaffolds via pyridinium ylide-mediated cyclization for DNA-encoded library construction was reported, featuring mild reaction conditions and broad substrate scope.