Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease

Hariharan Moorthy, Madhu Ramesh, Dikshaa Padhi, Prayasee Baruah and Thimmaiah Govindaraju

Mater. Horiz., 2024, 11, 3082
DOI: 10.1039/D4MH00023D

Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology

Kazuma Murakami, Haruka Kato, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose and Kazuhiro Irie

RSC Adv., 2020, 10, 19506
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The effects of platinum(iv) complexes on Aβ1–42 aggregation: a synergistic inhibition upon axial coordination

Sara La Manna, Daniele Florio, James A. Platts, Elisabetta Gabano, Mauro Ravera and Daniela Marasco

Dalton Trans., 2025, 54, 10416
DOI: 10.1039/D5DT00691K

Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo

Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu and Kazuhiro Irie

RSC Chem. Biol., 2022, 3, 1380
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Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review

Daniela Malafaia, Hélio M.T. Albuquerque and Artur M.S. Silva

European Journal of Medicinal Chemistry, 2021, 214, 113209
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Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii

Yohei Morishita, Kento Tsukada, Kazuma Murakami, Kazuhiro Irie and Teigo Asai

J. Nat. Prod., 2022, 85, 384
DOI: 10.1021/acs.jnatprod.1c00973

Resistance of nepetin and its analogs on the fibril formation of human islet amyloid polypeptide

Jufei Xu, Ting Zheng, Cong Zhao, Xiangyi Huang and Weihong Du

International Journal of Biological Macromolecules, 2021, 166, 435
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Advanced analytical methodologies in Alzheimer’s disease drug discovery

Angela De Simone, Marina Naldi, Daniele Tedesco, Manuela Bartolini, Lara Davani and Vincenza Andrisano

Journal of Pharmaceutical and Biomedical Analysis, 2020, 178, 112899
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Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Katiuscia Pagano, Simona Tomaselli, Henriette Molinari and Laura Ragona

Front. Neurosci., 2020, 14
DOI: 10.3389/fnins.2020.619667

Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation

Yuka Matsushima, Yumi Irie, Yusuke Kageyama, Jean‐Pierre Bellier, Ikuo Tooyama, Takahito Maki, Toshiaki Kume, Ryo C. Yanagita and Kazuhiro Irie

ChemBioChem, 2022, 23
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Tetracycline derivatives resist the assembly behavior of human islet amyloid polypeptide

Jufei Xu, Cong Zhao, Xiangyi Huang and Weihong Du

Biochimie, 2020, 174, 95
DOI: 10.1016/j.biochi.2020.04.012

Procyanidine resists the fibril formation of human islet amyloid polypeptide

Jufei Xu, Ting Zheng, Xiangyi Huang, Yanan Wang, Guowei Yin and Weihong Du

International Journal of Biological Macromolecules, 2021, 183, 1067
DOI: 10.1016/j.ijbiomac.2021.05.030

Asiatic acid and its derivatives: Pharmacological insights and applications

Chaowei Liang, Yongzhi Ma, Minni Ding, Fang Gao, Kewang Yu, Siyu Wang, Ying Qu, Huiming Hua and Dahong Li

European Journal of Medicinal Chemistry, 2025, 289, 117429
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Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease

Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu and Kazuhiro Irie

ACS Omega, 2020, 5, 21531
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Natural spirocyclic alkaloids and polyphenols as multi target dementia leads

Helmut M. Hügel, Nilamuni H. de Silva, Aimen Siddiqui, Ewan Blanch and Anthony Lingham

Bioorganic & Medicinal Chemistry, 2021, 43, 116270
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Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38

Ayaka Chikugo, Yumi Irie, Chihiro Tsukano, Ayumi Uchino, Takahito Maki, Toshiaki Kume, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama and Kazuhiro Irie

ACS Chem. Neurosci., 2022, 13, 2913
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Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC–MS/MS and Their Modulatory Effects on Amyloid β Aggregation

Kota Taniwa, Kazuma Murakami, Yoshiki Sakaguchi, Naotaka Izuo, Mizuho Hanaki, Nobuaki Sampa, Toshiaki Kume, Takahiko Shimizu and Kazuhiro Irie

J. Agric. Food Chem., 2023, 71, 14289
DOI: 10.1021/acs.jafc.3c02598

Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis

Mizuho Hanaki, Kazuma Murakami, Hiroki Gunji and Kazuhiro Irie

Bioorganic & Medicinal Chemistry Letters, 2022, 61, 128613
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Modified EDTA selectively recognized Cu2+ and its application in the disaggregation of β-amyloid-Cu (II)/Zn (II) aggregates

Renke Chang, Xiang Chen, Huijuan Yu, Guizhen Tan, Hongli Wen, Jianxin Huang and Zhifeng Hao

Journal of Inorganic Biochemistry, 2020, 203, 110929
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Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes

Hélio M. T. Albuquerque, Raquel Nunes da Silva, Marisa Pereira, André Maia, Samuel Guieu, Ana Raquel Soares, Clementina M. M. Santos, Sandra I. Vieira and Artur M. S. Silva

ACS Med. Chem. Lett., 2022, 13, 443
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New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β

Kazuhiro Irie

Bioscience, Biotechnology, and Biochemistry, 2020, 84, 1
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Heterometallic uranyl-organic frameworks incorporating manganese and copper: Structures, ammonia sorption and magnetic properties

Ge-Hua Wen, Qian Zou, Xin-Da Huang, Kun Zhang, Song-Song Bao and Li-Min Zheng

Polyhedron, 2021, 205, 115327
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Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models

Ayumi Uchino, Yumi Irie, Chihiro Tsukano, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Ryo C. Yanagita and Kazuhiro Irie

ACS Chem. Neurosci., 2022, 13, 2517
DOI: 10.1021/acschemneuro.2c00363

Sodium fusidate prevents protein aggregation of silk fibroin and offers new perspectives for human lens material disaggregation

Oktay K. Gasymov, Aida M. Mammedzade, Matanat J. Bakhishova, Aytaj J. Guliyeva, Laura Ragona and Henriette Molinari

Biophysical Chemistry, 2021, 279, 106680
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Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

Kazuma Murakami and Kazuhiro Irie

Molecules, 2019, 24, 2125
DOI: 10.3390/molecules24112125

Cholinesterase inhibitory potential of Dillenia suffruticosa chemical constituents and protective effect against Aβ−induced toxicity in transgenic Caenorhabditis elegans model

Saifullah Abubakar, Boon-Keat Khor, Kooi-Yeong Khaw, Vikneswaran Murugaiyah and Kit-Lam Chan

Phytomedicine Plus, 2021, 1, 100022
DOI: 10.1016/j.phyplu.2021.100022

Regulation of Artemisinin and Its Derivatives on the Assembly Behavior and Cytotoxicity of Amyloid Polypeptides hIAPP and Aβ

Jufei Xu, Cong Zhao, Xiangyi Huang and Weihong Du

ACS Chem. Neurosci., 2019, 10, 4522
DOI: 10.1021/acschemneuro.9b00385

Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer’s Disease Therapeutics

Kazuma Murakami, Shiori Horii, Mizuho Hanaki and Kazuhiro Irie

ACS Chem. Neurosci., 2021, 12, 3467
DOI: 10.1021/acschemneuro.1c00489

Triterpenoids impede the fibrillation and cytotoxicity of human islet amyloid polypeptide

Ting Zheng, Yanan Wang, Cong Zhao, Jufei Xu, Xiangyi Huang and Weihong Du

International Journal of Biological Macromolecules, 2022, 199, 189
DOI: 10.1016/j.ijbiomac.2021.12.127