Artificial intelligence-enabled hydrogels: innovations and applications

Abstract

Due to the excellent biocompatibility and adjustability, hydrogels have broadened their application in different fields, such as 3D printing, tissue engineering, drug delivery, and biosensing. However, traditional hydrogel research is confronted with low screening efficiency and insufficient design and characterization methods. In recent years, artificial intelligence (AI) has become a revolutionary tool for hydrogel research. AI technologies such as machine learning and deep learning have driven hydrogels towards intelligence and functionality. This article reviews the innovations of AI in the design and performance optimization of hydrogels, as well as their multi-scenario applications, such as 3D printing, environmental detection, and wound healing. Finally, the limitations, challenges and strategies for AI-driven hydrogel research are discussed. In conclusion, the cross-integration of AI and hydrogels has become an important trend of scientific research, providing new tools for the research of new hydrogel materials.

Graphical abstract: Artificial intelligence-enabled hydrogels: innovations and applications

Article information

Article type
Review Article
Submitted
29 Aug 2025
Accepted
08 Oct 2025
First published
30 Oct 2025

J. Mater. Chem. B, 2025, Advance Article

Artificial intelligence-enabled hydrogels: innovations and applications

S. Zhang, H. Wang, F. Liu, Y. Su, K. Han, Y. Liu, F. Guan, H. Liu and S. Ma, J. Mater. Chem. B, 2025, Advance Article , DOI: 10.1039/D5TB01944C

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