Issue 36, 2022

A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy

Abstract

Recently, disulfiram (DSF), approved by the FDA as an anti-alcoholic drug, has been proved as an effective antitumor drug after chelating with Cu2+. To overcome the shortage of intracellular Cu2+, we have constructed a dual gate-controlled intelligent nanoreactor (HA-DSF@HCuS@FePtMn, HDHF) via the ingenious combination of hollow copper sulfide (HCuS) nanoparticles, DSF and FePtMn nanocrystals. HDHF has a NIR-actuated gate and enzyme-actuated gate that could be opened in the hyaluronidase-abundant tumor microenvironment with NIR laser irradiation to trigger drug (DSF/FePtMn) release and synergistic therapy. Moreover, the FePtMn nanocrystals could continuously release Fe2+, which could catalyze H2O2 into highly cytotoxic hydroxyl radicals (˙OH), triggering chemodynamic therapy (CDT). When exposed to NIR laser, HCuS could collapse and release Cu2+, which could immediately chelate with DSF, forming the effective anticancer drug (Cu(DTC)2) and enabling DSF-based chemotherapy. More importantly, the efficient photothermal therapy (PTT) effect of HCuS could accelerate the FePtMn-based CDT and the release of Cu2+/DSF, improving tumor treatment efficiency. Thus, this study represents a distinctive paradigm of a dual gate-controlled intelligent nanoreactor enabled PTT-augmented DSF-based chemotherapy and FePtMn-based CDT for cancer nanotherapy.

Graphical abstract: A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy

Supplementary files

Article information

Article type
Paper
Submitted
05 Jul 2022
Accepted
09 Agu 2022
First published
02 Seb 2022

Nanoscale, 2022,14, 13113-13122

A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy

H. Zhang, W. Tang, Q. Gong, X. Yang, Y. Sun, Z. Dai, Z. Hu and X. Zheng, Nanoscale, 2022, 14, 13113 DOI: 10.1039/D2NR03676B

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