Ru(ii)-catalyzed oxidative C–H spiroannulation of 4-arylquinazolin-2-ones with alkynes

Abstract

A novel strategy has been devised for the synthesis of spiro[indene-1,4′-quinazolin]-2′(3′H)-one frameworks through Ru(II)-catalyzed tandem ortho-C–H bond activation and spiroannulation of 4-arylquinazolin-2-ones with alkynes. This is the first example of spiroannulation of 4-arylquinazolin-2-ones with internal alkynes. It is a versatile approach for synthesizing spiro[indene-1,4′-quinazolin]-2′(3′H)-one scaffolds with a broad substrate scope and high functional group tolerance.