Issue 4, 2022

Tumor-targeted nano-delivery system of therapeutic RNA

Abstract

The birth of RNAi technology has pioneered actionability at the molecular level. Compared to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With their flexible size, shape, structure, and accessible surface modification, non-viral vectors show great promise for application in RNA delivery. Different non-viral vectors have different ways of binding to RNA. Low immunotoxicity gives RNA significant advantages in tumor treatment. However, the delivery of RNA still has many limitations in vivo. This manuscript summarizes the size-targeting dependence of different organs, followed by a summary of nanovesicles currently in or undergoing clinical trials. It also reviews all RNA delivery systems involved in the current study, including natural, bionic, organic, and inorganic systems. It summarizes the advantages and disadvantages of different delivery methods, which will be helpful for future RNA vehicle design. It is hoped that this will be helpful for gene therapy of clinical tumors.

Graphical abstract: Tumor-targeted nano-delivery system of therapeutic RNA

Article information

Article type
Review Article
Submitted
05 Des 2021
Accepted
25 Jan 2022
First published
25 Jan 2022

Mater. Horiz., 2022,9, 1111-1140

Tumor-targeted nano-delivery system of therapeutic RNA

M. Wang, J. Zhao, H. Jiang and X. Wang, Mater. Horiz., 2022, 9, 1111 DOI: 10.1039/D1MH01969D

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