Issue 19, 2021

A metastasis suppressor Pt-dendrimer nanozyme for the alleviation of glioblastoma

Abstract

Nanozymes are nanostructure-based materials which mimic the enzymatic characteristics of natural enzymes. Biological applications of nanozymes have been highlighted in basic research, industry, and translational medicine as a new cutting-edge tool. In this work, and for the first time, we disclose a tumor alleviation property of a nanozyme that is made up of amine-terminated sixth-generation polyamidoamine dendrimers with encapsulated tiny platinum nanoparticles. We systematically conducted the synthesis and characterization of the dendrimer-encapsulated Pt nanoparticles (denoted Pt-dendrimer) and confirmed their enzymatic function (hydrogen peroxide (H2O2) decomposition) within various cell lines (normal, cancerous), including glioblastoma (GBM) cells. By understanding the effects of the Pt-dendrimer at the gene level, especially related to cancer cell metastasis, we have thoroughly demonstrated its ability for tumor alleviation and suppressing GBM migration, invasion, and adhesion. The present findings show great promise for the application of the nanozyme for use in GBM-related basic research as well as at clinical sites.

Graphical abstract: A metastasis suppressor Pt-dendrimer nanozyme for the alleviation of glioblastoma

Supplementary files

Article information

Article type
Paper
Submitted
28 Feb 2021
Accepted
22 Apu 2021
First published
24 Apu 2021

J. Mater. Chem. B, 2021,9, 4015-4023

A metastasis suppressor Pt-dendrimer nanozyme for the alleviation of glioblastoma

J. M. An, Y. Ju, J. H. Kim, H. Lee, Y. Jung, J. Kim, Y. J. Kim, J. Kim and D. Kim, J. Mater. Chem. B, 2021, 9, 4015 DOI: 10.1039/D1TB00425E

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