Issue 11, 2020

Ru(ii)-catalyzed C6-selective C–H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors

Abstract

In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(II) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy, and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility, and mechanistic studies were conducted. It offers a direct and efficient way to synthesize pyridone derivatives.

Graphical abstract: Ru(ii)-catalyzed C6-selective C–H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors

Supplementary files

Article information

Article type
Paper
Submitted
20 Des 2019
Accepted
27 Jan 2020
First published
11 Feb 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 6351-6355

Ru(II)-catalyzed C6-selective C–H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors

Y. Fu, Z. Wang, Q. Zhang, Z. Li, H. Liu, X. Bi and J. Wang, RSC Adv., 2020, 10, 6351 DOI: 10.1039/C9RA10749E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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