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Abstract | Cited by

The peptideBoc-Val-Phe-OMe 1 bearing sequence similarity with the central hydrophobic cluster (CHC) of Alzheimer's Aβ18-19peptide self-assembles to produce amyloid-like straight unbranched fibrils as examined by atomic force microscopy and Congo red assay. Single crystal X-ray diffraction offers the atomic level structure of the supramolecular parallel β-sheet aggregation and antiparallel separation between layers (cross-β-structure).

Graphical abstract: An amyloid-like fibril-forming supramolecular cross-β-structure of a model peptide: a crystallographic insight

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