Themed collection Metallomics in China

This editorial introduces the Metallomics in China themed issue, guest edited by Hongzhe Sun.

Rapid development of engineered nanomaterials (NMs) and growing biomedical applications necessitates new types of multifunctional NMs. Understanding behavior patterns of NMs in vivo and any potential health impacts are essential to ensure safety in the biomedical application of nanotechnologies.

The interactions between As and macro-nutrients, as well as micro-nutrients in rice plants, is reviewed.

HpSlyD interacts with HpHypB through its insert-in-flap (IF) domain and delivers Ni²⁺ to HpHypB, which induces the dimerization of HpHypB and enhances its GTPase activity.

We report herein new phosphorescent iridium(III) fructose complexes; their inhibited uptake by unmodified fructose, mitochondria-localization behavior and photocytotoxic activity can be utilized in the development of new tumor-selective photodynamic therapeutics.

The occurrence of HRPs in the proteomes of prokaryotes is found to be related to their habitats.

A 2.1 Å resolution crystal revealed oxo-Cu₂ clusters assembly in a metal-binding cleft of NgFbpA with two-tyrosine motif as ligands.

TS-PDE has one class of Zn²⁺ binding site and two classes of Cu²⁺ binding site, including the high affinity activator sites and the low affinity sites. The phosphodiesterase activity of TS-PDE relies on its disulfide bonds and bimetallic cluster.

Cobalt and nickel metalloproteome is involved in protein metabolism, carbonhydrate metabolism and gene expression regulation. Co- and Ni-binding motifs H(X)nH, M(X)nH and H(X)nM are identified.

Spatially histidine-rich clusters (HrCs) are commonly found in proteins and their presence closely correlates with transition metal ions.

2-DE, when coupled with SRXRF, was used to identify proteins of interest in E. coli upon Hg exposure.

The study suggests that elegant timing is essential for the introduction of EF-Ts into the elongation process and bismuth inhibits EF-Tu.

Hg can modulate Se activity via altering its distribution, accumulation and speciation in garlic which is grown under Se–Hg co-exposure conditions.

Mercury-containing protein was separated and characterized by 2D-HPLC-UV–ICP-MS.

Due to their metal binding capacities, both SelP-H and SelM′ suppressed Zn²⁺-induced Aβ₄₂ aggregation and thus exhibited antioxidant and neuroprotective functionalities.

PtCl₂(phen) preferentially binds to the Cu²⁺/Zn²⁺ coordination site in Aβ and turns metal ions to the secondary coordination site.

An acceleration effect on H₂O₂ activation by both His-43 and His-64 in an F43H Mn^IIIMb mutant was firstly demonstrated.

Possible mechanisms underlying vanadium compounds-induced antilipolytic effects in 3T3L1 adipocytes.

Chemical interactions of mercury species with Zn₇MT-2 under physiological conditions were evaluated using mass and CD spectroscopies.

Cytotoxicity of combined cryptotanshinone and arsenic trioxide treatment in multiple myeloma U266 cells.

Four ruthenium(II) asymmetric complexes were found to possess potent cellular uptake properties and induce HeLa cell apoptosis by acting on mitochondrial pathways.

Vanadium compounds increase PPARγ protein and modulate PPARγ phosphorylation in NIT-1 cells.