Themed collection Organic Chemistry in Green Chemistry: Key Highlights

Barochemistry, the use of high hydrostatic pressure, is a powerful green activation method that enables effective, scalable, energy efficient and solvent-free synthesis—offering a distinct advantages over other non-traditional activation techniques.

Green amine synthesis is assessed using the CHEM21 green metrics toolkit, offering a step-by-step guide for sustainability evaluation and promoting environmentally conscious transformations.

This review focuses on homogeneous recyclable catalytic systems for direct C–H bond functionalization in organic synthesis, eliminating pre-functionalization. It explores recyclable catalysts with various metals and metal-free approaches.

This article highlighted the recent demand for sustainable and resource efficient drug synthesis using electrochemical strategies.

The application of photocatalyzed Minisci-type reactions in LSF accelerates the discovery of drug candidates in a green way.

Chemistry in water, leveraging its solvent properties, provides a safer and more sustainable alternative to traditional organic solvent methods.

This review focuses on the use of ionic liquids (ILs) in green synthesis of 1,2,3-triazoles which critically screened, and summarized in two sections i.e., from alkynes and substrates other than alkynes using ILs as solvent, as catalyst and as both.

Se doping endows carbon materials with rich and versatile chemistry, thus transforming them into functional materials for sustainable technologies such as heterogeneous (electro)catalysis, energy conversion/storage devices, and pollutant removal.

A new and efficient strategy for the synthesis of 3-(alkyl/arylsulfonyl)benzothiophenes and benzoselenophenes through intramolecular alkyl/aryl transfer and SO₂ insertion process was developed.

We developed a novel dual catalytic strategy by combining NHC catalysis with photocatalysis for the carbonylation of alkenes, enabling the synthesis of valuable 1,4-dicarbonyl compounds.

Nickel-catalyzed electrochemical synthesis enables selective monoaryl and diarylamine formation from aryl halides and TMSN₃, marking a revolutionary progress in direct arylamine production.

New copper(II)-based catalysts were assembled, characterized, and applied for oxidative functionalization of α-pinene under micellar conditions in water, thus extending the scope of micellar catalysis to the valorization of terpenes.

An electrochemical method for selenylating tetrahydroquinolines with diselenides is presented. By tuning reaction conditions, C-3 selenylated quinolines and C-6 selenylated tetrahydroquinolines can be selectively synthesized with excellent outcomes.

In this study, we present the preparation and application of a new manganoporphyrin Hf-MOF catalyst, Hf-PCN-222(Mn) for the direct oxidative carboxylation of alkenes with CO₂, leading to the effective formation of cyclic organic carbonates (COCs).

An analysis of CHEM21 solvent categories reveals that green solvents are viable and often superior to oft-used toxic and hazardous solvents for catalytic hydrophosphination regardless of mechanism, substrate, or catalyst.

A photocatalytic methodology for the chemodivergent direct cross-coupling of simple alkanes with trifluoromethyl alkenes that enables the selective formation of gem-difluoroalkenes and trifluoromethyl alkanes is presented.

We herein describe a versatile electron–donor–acceptor (EDA) mediated thioesterification reaction using aryl sulfonium salt (acceptor) with potassium thioacid salts (donor) under visible light irradiation.

Biowaste promotes the self-blowing of isocyanate-free polyurethane (NIPU) liquid formulations and stabilizes the growing cells to deliver homogeneous foams.

A photoelectrochemical approach for the carboacylation/silanoylation of alkenes with alkanes/hydrosilanes is described. The method offers a new perspective for chemists to rapidly obtain various ketones with high levels of structural complexity.

A novel photocatalytic acylation strategy was developed harnessing tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst to facilitate the direct coupling of aldehydes with N-heterocycles at ambient temperature.

In situ-generated protonated aromatic hydrocarbons overcome their intrinsic electronic properties to serve as catalytic electron acceptors, avoiding the use of photocatalysts, metals, and redox reagents to achieve fluoroalkylation.

Herein, we demonstrate a solvent-free and cost-effective mechanochemical electrophilic thiocyanation of indoles and imidazo[1,2-a]pyridines and tandem double C–H activation leading to the formation of C-2 aryl and C-3 thiocyano indoles in a mixer-mill.

Operationally simple photo-nickel C(sp²)–S cross-coupling with a reusable heterogeneous photocatalyst.

Aiming at the development of low-impact synthetic pathways, we herein report the simultaneous employment of different tools to improve the overall sustainability of the Suzuki–Miyaura (SM) cross-coupling with a circular economy approach.

A metal-free and catalyst-free strategy is reported to achieve N–H insertions by coupling N-tosylhydrazones with diverse amines including aminopyridines, anilines, aliphatic amines, and other nucleophiles such as imidazoles and indoles.

A new photoelectrocatalytic mode permits the synthesis of polycyclic pyrimidin-4-ones through dehydrogenative cyclization of malonates with unactivated alkenes.

The electrochemical bromination of enamide derivatives was developed using inexpensive and non-toxic sodium bromide (NaBr).

A practical electrosynthesis of aryl sulfonyl fluorides from nitroarenes is described. Cheap N-methylimidazolium p-toluenesulfonate has been found to be an effective additive, promoting the desired fluorosulfonylation under very mild conditions.

Herein, we report a mechanochemical-assisted decarboxylative sulfonylation of α,β-unsaturated carboxylic acids with sodium sulfinate salts using potassium iodide as an activator under water-assisted grinding conditions.

A unique imine-based covalent organic framework heterogeneous catalyst with missing-linker defects was designed and synthesized, and the catalyst exhibited excellent photocatalytic activity for efficient synthesis of tetrahydroquinolines.

An electrochemical epoxidation of unactivated olefins with water as the source of oxygen has been developed.