In this study, electrooxidation of tetrahydroisoquinolines was coupled with the generation of hydrogen on a designed electrode. High selectivity was shown with the generation of dihydroisoquinolines.
The chirality introduced at the C1 position of 1-substituted-1,2,3,4-tetrahydroisoquinolines, obtained by four methods of enantioselective reduction of 1-substituted-3,4-dihydroisoquinolines, are vital for various biological activities.
Green, red-light-induced THIQ oxidation and functionalization using spinach-extracted chlorophyll as a photocatalyst, yielding neuroprotective compound 4iin vitro.
Organocatalytic enantioselective cross-dehydrogenative coupling reaction provides a great opportunity for the synthesis of highly enantioenriched molecules. In this review, recent progress in this field is summarized.
This work reports a protocol for the direct α-cyanation/N-acylation of 1,2,3,4-tetrahydroisoquinolines via a one-pot photoredox and Reissert-type reaction using air as the oxidant and acyl cyanide as acyl and cyano source at ambient temperature.