Alexia Lourtie, Lisa Mussoi, Guillaume Caulier, Mathilde Isorez, Hanitriala Mahavory, Tonia Tolodraza, Guyliann Engels, Frank David, Igor Eeckhaut and Jérôme Mallefet

Symbiosis, 2024, 94, 107
DOI: 10.1007/s13199-024-01018-x

A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin‐Based Drugs

Haili Zhang, Xuyang Li, Zhen Hui, Shipeng Huang, Mingwei Cai, Wenguang Shi, Yang Lin, Jie Shen, Minghao Sui, Qiliang Lai, Zongze Shao, Jie Dou, Xiaozhou Luo, Yun Ge and Xiaoyu Tang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202318784

Enzymatic Synthesis Assisted Discovery of Proline‐Rich Macrocyclic Peptides in Marine Sponges

Ipsita Mohanty, Nguyet A. Nguyen, Samuel G. Moore, Jason S. Biggs, David A. Gaul, Neha Garg and Vinayak Agarwal

ChemBioChem, 2021, 22, 2614
DOI: 10.1002/cbic.202100275

Evaluating the impact of an increase in sea water temperature on the palmerolides of the Antarctic benthic tunicate Synoicum adareanum

Andrea Prófumo, Conxita Avila and Adele Cutignano

Science of The Total Environment, 2025, 998, 180289
DOI: 10.1016/j.scitotenv.2025.180289

Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them

Javier Santos-Aberturas and Natalia Vior

Antibiotics, 2022, 11, 195
DOI: 10.3390/antibiotics11020195

Metabolomic tools used in marine natural product drug discovery

Kevin Andrew Stuart, Keira Welsh, Molly Clare Walker and RuAngelie Edrada-Ebel

Expert Opinion on Drug Discovery, 2020, 15, 499
DOI: 10.1080/17460441.2020.1722636

Animal biosynthesis of complex polyketides in a photosynthetic partnership

Joshua P. Torres, Zhenjian Lin, Jaclyn M. Winter, Patrick J. Krug and Eric W. Schmidt

Nat Commun, 2020, 11
DOI: 10.1038/s41467-020-16376-5

Ancient defensive terpene biosynthetic gene clusters in the soft corals

Paul D. Scesa, Zhenjian Lin and Eric W. Schmidt

Nat Chem Biol, 2022, 18, 659
DOI: 10.1038/s41589-022-01027-1

The Anti-Proliferative Activity of Secondary Metabolite from the Marine Streptomyces sp. against Prostate Cancer Cells

Hung-Yu Lin, Yong-Shiou Lin, Shou-Ping Shih, Sung-Bau Lee, Mohamed El-Shazly, Ken-Ming Chang, Yu-Chen S. H. Yang, Yi-Lun Lee and Mei-Chin Lu

Life, 2021, 11, 1414
DOI: 10.3390/life11121414

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity

Roberta M. O’Connor, Felix J. Nepveux V, Jaypee Abenoja, Gregory Bowden, Patricia Reis, Josiah Beaushaw, Rachel M. Bone Relat, Iwona Driskell, Fernanda Gimenez, Michael W. Riggs, Deborah A. Schaefer, Eric W. Schmidt, Zhenjian Lin, Daniel L. Distel, Jon Clardy, Timothy R. Ramadhar, David R. Allred, Heather M. Fritz, Pradipsinh Rathod, Laura Chery, John White and Boris Striepen

PLoS Pathog, 2020, 16, e1008600
DOI: 10.1371/journal.ppat.1008600

Ascidian Toxins with Potential for Drug Development

Dianne J. Watters

Marine Drugs, 2018, 16, 162
DOI: 10.3390/md16050162

Discovery and Biosynthesis of Ureidopeptide Natural Products Macrocyclized via Indole N‐acylation in Marine Microbulbifer spp. Bacteria

Weimao Zhong, Jessica M. Deutsch, Dongqi Yi, Nadine H. Abrahamse, Ipsita Mohanty, Samuel G. Moore, Andrew C. McShan, Neha Garg and Vinayak Agarwal

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300190

Non-Peptidic Small Molecule Components from Cone Snail Venoms

Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera and Eric W. Schmidt

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.655981

Seasonal dynamics and starvation impact on the gut microbiome of urochordate ascidian Halocynthia roretzi

Jiankai Wei, Hongwei Gao, Yang Yang, Haiming Liu, Haiyan Yu, Zigui Chen and Bo Dong

anim microbiome, 2020, 2
DOI: 10.1186/s42523-020-00048-2

Characterizing the evolution of defense in a tripartite marine symbiosis using adaptive dynamics

Prerna Singh, Marjolein Bruijning, Gavriela D Carver, Mohamed S Donia and Charlotte Jessica E Metcalf

Evolution Letters, 2025, 9, 105
DOI: 10.1093/evlett/qrae052

Chemical Ecology of Marine Sponges: New Opportunities through “-Omics”

Valerie J Paul, Christopher J Freeman and Vinayak Agarwal

Integrative and Comparative Biology, 2019, 59, 765
DOI: 10.1093/icb/icz014

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Xiaoju Dou and Bo Dong

Marine Drugs, 2019, 17, 670
DOI: 10.3390/md17120670

“From Large-Scale Collections to the Potential Use of Genomic Techniques for Supply of Drug Candidates”

David J. Newman

Front. Mar. Sci., 2018, 5
DOI: 10.3389/fmars.2018.00401

Isolation, identification, and pathogenicity of Pseudoalteromonas aliena associated with oyster disease outbreaks in summer

Shuyi Mu, Jiejie Sun, Lei Gao, Yinan Li, Zihan Wang, Renle Chang, Jun Jiang, Liyan Wang, Lingling Wang, Linsheng Song, Warish Ahmed, Jialong Yang and Jiang-Feng Lan

Microbiol Spectr, 2025, 13
DOI: 10.1128/spectrum.00173-25

A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters

Brett C. Covington, Fei Xu and Mohammad R. Seyedsayamdost

Annu. Rev. Biochem., 2021, 90, 763
DOI: 10.1146/annurev-biochem-081420-102432

Comparative Metagenomic Analysis of Biosynthetic Diversity across Sponge Microbiomes Highlights Metabolic Novelty, Conservation, and Diversification

Catarina Loureiro, Anastasia Galani, Asimenia Gavriilidou, Maryam Chaib de Mares, John van der Oost, Marnix H. Medema, Detmer Sipkema and Laura M. Sanchez

mSystems, 2022, 7
DOI: 10.1128/msystems.00357-22

The biosynthetic diversity of the animal world

Joshua P. Torres and Eric W. Schmidt

Journal of Biological Chemistry, 2019, 294, 17684
DOI: 10.1074/jbc.REV119.006130

Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine Microbulbifer Bacteria

Yifan Tang, Weimao Zhong, Longping Fu, Emmanuel Asante, Anastasiia Kostenko, F. N. U. Vidya, Paige Mandelare-Ruiz, Tamilore T. Adeogun, Gabriel P. Anderson, Benjamin E. Edmonds, Oscar Fang, Michelle Han, Alia S. Hollingsworth, Amna R. Ingham, Carlyn R. Kirby, Alice Landrum, Connor R. Mack, Nikki S. Nobari, Emma J. Oswald, Cecilia L. Polevoy, Yasmin Sharifian, Timothy J. So, Joelee R. Stokes, Reniya S. Thompson, Rishabh Vuthamaraju, Elaine C. Wang, William H. Yang, Alison E. Onstine, Valerie J. Paul, Ronghu Wu, Allegra T. Aron and Vinayak Agarwal

ACS Chem. Biol., 2025
DOI: 10.1021/acschembio.5c00507

Precursor-Guided Mining of Marine Sponge Metabolomes Lends Insight into Biosynthesis of Pyrrole–Imidazole Alkaloids

Ipsita Mohanty, Samuel G. Moore, Dongqi Yi, Jason S. Biggs, David A. Gaul, Neha Garg and Vinayak Agarwal

ACS Chem. Biol., 2020, 15, 2185
DOI: 10.1021/acschembio.0c00375

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman and Jörn Piel

Nat. Chem., 2019, 11, 931
DOI: 10.1038/s41557-019-0323-9

Comparative metabolomic analysis reveals shared and unique chemical interactions in sponge holobionts

Shan Zhang, Weizhi Song, Louis-Félix Nothias, Sneha P. Couvillion, Nicole Webster and Torsten Thomas

Microbiome, 2022, 10
DOI: 10.1186/s40168-021-01220-9

Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire

Jack G. Ganley and Emily R. Derbyshire

Molecules, 2020, 25, 625
DOI: 10.3390/molecules25030625

Presence of Bromotyrosine Alkaloids in Marine Sponges Is Independent of Metabolomic and Microbiome Architectures

Ipsita Mohanty, Subhasish Tapadar, Samuel G. Moore, Jason S. Biggs, Christopher J. Freeman, David A. Gaul, Neha Garg, Vinayak Agarwal and Matthew F. Traxler

mSystems, 2021, 6
DOI: 10.1128/msystems.01387-20

Elucidation of the Tailoring Steps in Julichrome Biosynthesis by Marine Gastropod Mollusk-Associated Streptomyces sampsonii SCSIO 054

Xiaoqi Ji, Yuliang Dong, Chunyao Ling, Zhenbin Zhou, Qinglian Li and Jianhua Ju

Org. Lett., 2020, 22, 6927
DOI: 10.1021/acs.orglett.0c02469

Metabolomics and Marine Biotechnology: Coupling Metabolite Profiling and Organism Biology for the Discovery of New Compounds

Miriam Reverter, Sven Rohde, Christelle Parchemin, Nathalie Tapissier-Bontemps and Peter J. Schupp

Front. Mar. Sci., 2020, 7
DOI: 10.3389/fmars.2020.613471

Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii

Phan Thi Hoai Trinh, Anton N. Yurchenko, Olga O. Khmel, Trang Vo Thi Dieu, Ngo Thi Duy Ngoc, Elena V. Girich, Alexander S. Menshov, Natalya Y. Kim, Ekaterina A. Chingizova, Tran Thi Thanh Van, Jong Seok Lee, Hyi-Seung Lee and Ekaterina A. Yurchenko

Molecules, 2022, 27, 7650
DOI: 10.3390/molecules27217650

An Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes

Nguyet A. Nguyen, Zhenjian Lin, Ipsita Mohanty, Neha Garg, Eric W. Schmidt and Vinayak Agarwal

J. Am. Chem. Soc., 2021, 143, 10221
DOI: 10.1021/jacs.1c03474

Spongisulfins A-C, three S-bridged angucycline dimers from Spongiactinospora rosea LHW63015 and their gut epithelium protective activity in Drosophila melanogaster

Weizhuo Tang, Die Zhang, Jing Xu, Shuping Wang, Bin Wei and Lei Li

Arabian Journal of Chemistry, 2024, 17, 105687
DOI: 10.1016/j.arabjc.2024.105687

Dimeric pyrrole-imidazole alkaloids: sources, structures, bioactivities and biosynthesis

Mei-Jun Chu, Meng Li and Yongda Zhao

Bioorganic Chemistry, 2023, 133, 106332
DOI: 10.1016/j.bioorg.2022.106332

Limited Metabolomic Overlap between Commensal Bacteria and Marine Sponge Holobionts Revealed by Large Scale Culturing and Mass Spectrometry-Based Metabolomics: An Undergraduate Laboratory Pedagogical Effort at Georgia Tech

Jessica M. Deutsch, Madison O. Green, Priyanka Akavaram, Ashleigh C. Davis, Sarth S. Diskalkar, Isabelle A. Du Plessis, Hannah A. Fallon, Emma M. Grason, Emma G. Kauf, Zoe M. Kim, Jeffrey R. Miller, Abby L. Neal, Tatiana Riera, Sofie-Ellen Stroeva, Jollin Tran, Vivi Tran, Azucena Velgara Coronado, Vanessa Velgara Coronado, Benjamin T. Wall, Chung mo Yang, Ipsita Mohanty, Nadine H. Abrahamse, Christopher J. Freeman, Cole G. Easson, Cara L. Fiore, Alison E. Onstine, Naima Djeddar, Shweta Biliya, Anton V. Bryksin, Neha Garg and Vinayak Agarwal

Marine Drugs, 2023, 21, 53
DOI: 10.3390/md21010053

Bacteria Associated with Benthic Invertebrates from Extreme Marine Environments: Promising but Underexplored Sources of Biotechnologically Relevant Molecules

Angelina Lo Giudice and Carmen Rizzo

Marine Drugs, 2022, 20, 617
DOI: 10.3390/md20100617

The impact of decreasing biodiversity on novel drug discovery: is there a serious cause for concern?

David J. Newman

Expert Opinion on Drug Discovery, 2019, 14, 521
DOI: 10.1080/17460441.2019.1593370

A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin‐Based Drugs

Haili Zhang, Xuyang Li, Zhen Hui, Shipeng Huang, Mingwei Cai, Wenguang Shi, Yang Lin, Jie Shen, Minghao Sui, Qiliang Lai, Zongze Shao, Jie Dou, Xiaozhou Luo, Yun Ge and Xiaoyu Tang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202318784

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

Asimenia Gavriilidou, Thomas Andrew Mackenzie, Pilar Sánchez, José Ruben Tormo, Colin Ingham, Hauke Smidt and Detmer Sipkema

Marine Drugs, 2021, 19, 75
DOI: 10.3390/md19020075

Aquatic Productivity under Multiple Stressors

Donat-P. Häder and Kunshan Gao

Water, 2023, 15, 817
DOI: 10.3390/w15040817

Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives

Kris Cooreman, Bart De Spiegeleer, Christof Van Poucke, David Vanavermaete, Daan Delbare, Evelien Wynendaele and Bavo De Witte

Environmental Toxicology and Pharmacology, 2023, 102, 104254
DOI: 10.1016/j.etap.2023.104254

Chromosome-level genome assembly of the sacoglossan sea slug Elysia timida (Risso, 1818)

Lisa Männer, Tilman Schell, Julia Spies, Carles Galià-Camps, Damian Baranski, Alexander Ben Hamadou, Charlotte Gerheim, Kornelia Neveling, Eric J. N. Helfrich and Carola Greve

BMC Genomics, 2024, 25
DOI: 10.1186/s12864-024-10829-7

Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination

Sarah P. Niehs, Jana Kumpfmüller, Benjamin Dose, Rory F. Little, Keishi Ishida, Laura V. Flórez, Martin Kaltenpoth and Christian Hertweck

Angewandte Chemie, 2020, 132, 23322
DOI: 10.1002/ange.202005711

Multi-Omic Profiling of Melophlus Sponges Reveals Diverse Metabolomic and Microbiome Architectures that Are Non-overlapping with Ecological Neighbors

Ipsita Mohanty, Sheila Podell, Jason S. Biggs, Neha Garg, Eric E. Allen and Vinayak Agarwal

Marine Drugs, 2020, 18, 124
DOI: 10.3390/md18020124

Mass spectrometry-based metabolomics in microbiome investigations

Anelize Bauermeister, Helena Mannochio-Russo, Letícia V. Costa-Lotufo, Alan K. Jarmusch and Pieter C. Dorrestein

Nat Rev Microbiol, 2022, 20, 143
DOI: 10.1038/s41579-021-00621-9

Discovery of an Antarctic Ascidian-Associated Uncultivated Verrucomicrobia with Antimelanoma Palmerolide Biosynthetic Potential

Alison E. Murray, Chien-Chi Lo, Hajnalka E. Daligault, Nicole E. Avalon, Robert W. Read, Karen W. Davenport, Mary L. Higham, Yuliya Kunde, Armand E. K. Dichosa, Bill J. Baker, Patrick S. G. Chain and Barbara J. Campbell

mSphere, 2021, 6
DOI: 10.1128/mSphere.00759-21

Short macrocyclic peptides in sponge genomes

Zhenjian Lin, Vinayak Agarwal, Ying Cong, Shirley A. Pomponi and Eric W. Schmidt

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2314383121

Is the bacterial leaf nodule symbiosis obligate for Psychotria umbellata? The development of a Burkholderia-free host plant

Arne Sinnesael, Olivier Leroux, Steven B. Janssens, Erik Smets, Bart Panis, Brecht Verstraete and Peter Mergaert

PLoS ONE, 2019, 14, e0219863
DOI: 10.1371/journal.pone.0219863

A microbial factory for defensive kahalalides in a tripartite marine symbiosis

Jindong Zan, Zhiyuan Li, Ma. Diarey Tianero, Jeanette Davis, Russell T. Hill and Mohamed S. Donia

Science, 2019, 364
DOI: 10.1126/science.aaw6732

Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals

Lik Tong Tan

Marine Drugs, 2023, 21, 174
DOI: 10.3390/md21030174

The Bi-Functional Paxilline Enriched in Skin Secretion of Tree Frogs (Hyla japonica) Targets the KCNK18 and BKCa Channels

Chuanling Yin, Fanpeng Zeng, Puyi Huang, Zhengqi Shi, Qianyi Yang, Zhenduo Pei, Xin Wang, Longhui Chai, Shipei Zhang, Shilong Yang, Wenqi Dong, Xiancui Lu and Yunfei Wang

Toxins, 2023, 15, 70
DOI: 10.3390/toxins15010070

Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination

Sarah P. Niehs, Jana Kumpfmüller, Benjamin Dose, Rory F. Little, Keishi Ishida, Laura V. Flórez, Martin Kaltenpoth and Christian Hertweck

Angew Chem Int Ed, 2020, 59, 23122
DOI: 10.1002/anie.202005711