Issue 23, 2023

Nucleophilic organocatalysis involving radical intermediates

Abstract

The field of nucleophilic organocatalysis has garnered enormous interest and utility in the past two decades. Additionally, radical chemistry, mainly driven by the research progress in photocatalysis and electrocatalysis, has regained extensive attention. The unique reactivity of free radicals, which is different that of from closed-shell species, provides a solution to issues in electron-pair-mechanism-based catalysis. In this review, we highlight the advances in single-electron nucleophilic organocatalysis. We have separated the review into amine, N-heterocyclic carbene (NHC) and phosphine sections according to the type of organocatalyst. The strategies for the generation of radical species and the formation of new bonds are emphasized in the discussions of specific reactions. The final section provides a brief outline of the relationships among different nucleophilic organocatalysis and the prospects for future development.

Graphical abstract: Nucleophilic organocatalysis involving radical intermediates

Article information

Article type
Review Article
Submitted
05 Sep 2023
Accepted
13 Okt 2023
First published
17 Okt 2023

Org. Chem. Front., 2023,10, 6021-6040

Nucleophilic organocatalysis involving radical intermediates

H. Yang, Org. Chem. Front., 2023, 10, 6021 DOI: 10.1039/D3QO01435E

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