Issue 5, 2023

Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics

Abstract

Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus.

Graphical abstract: Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics

Supplementary files

Article information

Article type
Communication
Submitted
21 Okt 2022
Accepted
01 Dez 2022
First published
01 Dez 2022

Chem. Commun., 2023,59, 587-590

Author version available

Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics

K. Zhao, J. K. Vasquez and H. E. Blackwell, Chem. Commun., 2023, 59, 587 DOI: 10.1039/D2CC05733F

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