Issue 39, 2012
From the journal:

Chemical Communications

Application of photoactive yellow protein as a photoresponsive module for controlling hemolytic activity of staphylococcal α-hemolysin†

Mihoko Ui,a   Yoshikazu Tanaka,b   Yasuyuki Araki,a   Takehiko Wada,a   Toshiaki Takei,cd   Kouhei Tsumoto,cd   Sumire Endoa  and  Kazushi Kinbara*a  

* Corresponding authors

a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan
E-mail: kinbara@tagen.tohoku.ac.jp
Fax: +81 22-217-5612
Tel: +81 22-217-5612

b Creative Research Institution “Sousei”, Hokkaido University, North-21, West-10, Kita-ku, Sapporo, Japan

c Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

d Department of Medical Genome Sciences, Graduate School of Engineering, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277 8562, Japan

Abstract

A chimeric protein (N-PYP-Hla), consisting of staphylococcal pore-forming toxin α-hemolysin (Hla) and photoactive yellow protein (PYP), exhibited photoresponsive hemolytic activities, where visible light irradiation gave rise to retardation of hemolysis at 25 °C.

Graphical abstract: Application of photoactive yellow protein as a photoresponsive module for controlling hemolytic activity of staphylococcal α-hemolysin

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Article information

DOI
https://doi.org/10.1039/C2CC18118E
Article type
Communication
Submitted
28 Dec 2011
Accepted
20 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4737-4739

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Application of photoactive yellow protein as a photoresponsive module for controlling hemolytic activity of staphylococcal α-hemolysin

M. Ui, Y. Tanaka, Y. Araki, T. Wada, T. Takei, K. Tsumoto, S. Endo and K. Kinbara, Chem. Commun., 2012, 48, 4737 DOI: 10.1039/C2CC18118E

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